Refining Lower Limb TMS: Identifying MEPs in Resting Ipsilateral Muscles
This study quantifies motor evoked potentials in the non-target resting leg, offering methodological clarity for transcranial magnetic stimulation.
Demographics Influence Etiology in 2,052 Patients With Late-Onset Seizures
A multicenter study finds that while stroke remains common, neurodegeneration and unexplained causes dominate the geriatric epilepsy profile.
Selective HDAC6 Inhibition Improves Motor Function in Preclinical ALS Models
A CNS-penetrant small molecule restores protein clearance and axonal transport, reducing neurofilament levels and TDP-43 pathology.
Intravenous Magnesium Sulfate Reduces Rescue Analgesia for Acute Headache
A randomized trial finds adjunctive magnesium sulfate increases treatment success and patient satisfaction, despite pain reduction not meeting clinica
Multimodal AI System Matches Clinicians in Simulated Telehealth Diagnostics
A new AI system, multimodal AMIE, integrates diverse data types to achieve high diagnostic accuracy and conversational quality in simulated telehealth
ALS Subtypes Show Distinct Immune Remodeling, Linking Blood Changes to Spinal Cord Damage
A new study details specific immune cell dynamics and molecular programs in ALS, revealing distinct patterns across disease subtypes.
Thrombectomy Improves Functional Independence in Medium-Vessel Occlusion Stroke
A randomized trial shows endovascular thrombectomy increases functional independence but also raises symptomatic intracranial hemorrhage risk in mediu
SSPOP Mutations Linked to Pediatric Epilepsy and Developmental Disorders
Researchers identify pathogenic variants in a supposed pseudogene, expanding the diagnostic landscape for unexplained neurodevelopmental delay.
Long-Duration Levodopa Response Distinguishes Parkinson's, Predicts Outcomes
A study details how sustained levodopa motor improvement helps differentiate parkinsonian syndromes and offers prognostic insights for PD.
Alantolactone and Temozolomide Combination Targets Glioblastoma Stemness, Lipid Metabolism
Preclinical findings suggest alantolactone combined with temozolomide may overcome glioblastoma resistance by modulating the Hippo pathway.
High-Impact Sports Linked to 4-15-Fold Increased MND/ALS Risk
A scoping review identifies a significant association between professional participation in high-impact sports and elevated motor neurone disease risk
Neuroimaging Biotypes May Guide MDD Treatment, Improve Remission
Functional MRI-derived circuit profiles could personalize major depressive disorder therapy, potentially doubling remission rates.