Plasma p-Tau217 Matches PET for Modeling Alzheimer's Timelines
Plasma p-tau217 accurately estimates the onset of amyloid and tau pathology, offering an accessible alternative to expensive PET scans.
TBI and Depression Nearly Triple 10-Year Dementia Risk in Veterans
A cohort study of 245,949 veterans shows TBI, depression, and military exposures like Agent Orange significantly increase Alzheimer's risk.
CD4+ T-Cells Infiltrate Hypocretin Region in Narcolepsy Type 1
Postmortem analysis shows an 11-fold increase in CD4+ T-cells specifically within the hypothalamus, supporting an autoimmune etiology.
Industrial Dust and Smoking Combine to Increase Multiple Sclerosis Risk
Patients exposed to occupational dust who also smoke and carry the HLA-DRB1*15:01 allele face an 11-fold higher rate of multiple sclerosis.
NMDA Receptor Ablation in Adolescent Mice Triggers Synaptic Rebound
Removing NMDA receptors in the adolescent mouse prefrontal cortex causes an initial spine loss followed by a compensatory synaptic rebound.
Plasma GFAP and NfL Predict Long-Term Mortality in Older Adults
Elevated baseline levels of GFAP and NfL strongly correlate with future risk of all-cause, dementia, and cardiovascular death.
Algorithm Predicts Parkinsonism Pathology From Clinical Symptoms
A machine learning tool trained on brain bank data uses 23 clinical parameters to accurately predict post-mortem pathology in parkinsonism.
Inhibiting USP22 Halts Periodontitis-Linked Brain Inflammation in Mice
Knocking down the enzyme USP22 in mice prevents the periodontal pathogen P. gingivalis from degrading blood-brain barrier tight junctions.
Women Face Worse Functional Recovery After Intensive Care EEG
Despite similar acute management and mortality, critically ill women are half as likely as men to achieve favorable long-term recovery.
Baseline Breathing Patterns Predict Post-Seizure Hypoxemia Severity
Measuring respiratory variability between seizures may help identify epilepsy patients at highest risk for severe oxygen desaturation.
Brain Imaging Maps How Deep Brain Stimulation Alters Parkinson's Circuits
Extensive functional MRI data from 14 patients reveals that cortical connectivity patterns can predict clinical outcomes of stimulation.
Zorevunersen Cuts Convulsive Seizures in Children With Dravet Syndrome
The investigational antisense therapy reduced convulsive-seizure frequency by up to 90.91% and improved adaptive behavior over 36 months.