Lactate Enzyme Overexpression Enhances Remyelination in Animal Models
Restoring glycolysis and lactate production in oligodendrocyte precursors overcomes epigenetic silencing to stimulate myelin repair.
Serum Neurofilament Light Chain Identifies Subclinical Axonal Injury in SMA Neonates
Elevated serum neurofilament light chain levels predict two-year motor outcomes and reveal active denervation before clinical symptoms appear.
CTA Plaque-RADS Predicts Ipsilateral Recurrence in Embolic Stroke
A standardized scoring system for nonstenotic carotid plaques identifies a distinct ESUS subgroup with a threefold higher risk of recurrence.
Hippocampus-Thalamus Circuit Drives Contextual Hyperactivity in PTSD Mouse Model
A specific glutamatergic pathway may be a therapeutic target for context-dependent arousal symptoms.
Oral Celecoxib and Ciprofloxacin Slow Functional Decline in ALS
A phase 2b trial shows the fixed-dose combination is safe and reduces the risk of severe complications over 18 months in early-stage ALS.
Cognitive Status Remains Key Predictor of Dementia Risk Alongside p-tau181
ARIC data show that while p-tau181 is prognostic, the absolute risk of dementia remains low in cognitively unimpaired individuals.
Caffeinated Coffee and Tea Lower Dementia Risk; Decaf Shows No Benefit
A 43-year prospective study of 131,821 adults reveals that 2 to 3 cups of caffeinated coffee daily significantly reduces incident dementia.
Glioblastoma Cells Hijack Fetal Neural Stem Cell Motors to Spread
Glioblastoma cells use the same dynein-driven and actomyosin-dependent motors as fetal neural stem cells to invade surrounding tissue.
Intracortical Implant Enables Paralyzed Patients to Type 22 Words Per Minute
By decoding attempted finger movements, a neuroprosthesis allows patients with tetraplegia to type on a virtual QWERTY keyboard.
East Asian Registry Details Distinct Demyelinating Disease Profile
A Korean registry reveals that antibody-mediated conditions account for nearly half of central nervous system demyelinating cases.
Continuous Rocuronium Yields Modest Intracranial Pressure Reductions
A retrospective analysis reveals that continuous neuromuscular blockade lowers intracranial pressure by only 1 to 2 mm Hg in severe cases.
White Matter Damage Drives Cognitive Decline via Two Distinct Pathways
In amyloid-negative patients, periventricular lesions directly impair memory but indirectly drive executive dysfunction via hypometabolism.