Pre-SRS PD-1 Inhibitor Use Linked to Increased Neurological Deficits, Mortality
A multi-institutional study suggests administering PD-1 inhibitors before stereotactic radiosurgery in glioma patients may worsen outcomes.
Younger Brain Age Buffers Cognitive Impact of Tau Pathology
Structural brain integrity, but not education level, modifies the link between p-tau217 and cognitive performance in older adults.
4-Hydroxybenzoic Acid Restores Endogenous Coenzyme Q10 in COQ2-Deficient Patient
A first-in-human trial shows 4-HBA bypasses biosynthetic blocks to improve neurological and renal outcomes in primary CoQ10 deficiency.
Semantic-Metacognitive Therapy Improves Naming in Semantic Variant PPA
A single-case experimental study shows specific speech therapy can improve naming performance in individuals with semantic variant primary…
POD1 Prolactin Levels Predict Long-Term Outcomes After Prolactinoma Resection
Postoperative day 1 prolactin levels help stratify risk for hyperprolactinemia rebound and recurrence, especially with prior dopamine agonist use.
Platelet mTOR Pathway Drives Neuropathogenesis in Cerebral Malaria
A new study identifies the mechanistic target of rapamycin (mTOR) in platelets as a key mediator of brain injury in experimental cerebral malaria.
Autonomic Burden Linked to Cognitive Fluctuations in Lewy Body Dementia
A longitudinal study finds autonomic symptom severity correlates with neuropsychiatric burden and reduced caregiver quality of life.
Anterior Temporal Atrophy Precedes Semantic Dementia Symptoms by Five Years
Large-scale MRI analysis identifies a prolonged prodromal phase and quantifies the prevalence of incidental anterior temporal lobe loss.
Amateur Soccer Heading Linked to Acute Elevations in Neural Damage Biomarkers
A prospective study found that heading in amateur soccer acutely increases blood levels of p-tau217 and S100B, with dose-response relationships.
Cervical Spinal Cord Injury Linked to Higher Depression Risk Than Lower-Level Injuries
A nationwide cohort study reveals patients with cervical SCI face a significantly elevated risk of depression compared to those with thoracic/lumbar.
Adenoviral Protein Reactivity Linked to Guillain-Barré Syndrome After COVID-19
Patients with post-infection or post-vaccination GBS show heightened antibody responses to adenoviruses, suggesting a shared trigger.
Stereotactic Radiosurgery Improves Tumor Control, Overall Outcomes for Older VS Patients
A retrospective study indicates stereotactic radiosurgery significantly reduces vestibular schwannoma progression and improves neurological outcomes.