Nature Aging
Cohort Study
APOE ε2 and ε4 Drive Alzheimer's Risk Through Distinct Molecular Pathways
A multicohort proteomic analysis reveals allele-specific protein signatures influencing Alzheimer's disease risk and progression.
Nature Aging
Cohort Study
Reduced ULK1 Links Impaired Cellular Clearance to Alzheimer's Pathology
Lower levels of ULK1 correlate with Alzheimer's disease, and its upregulation improves pathology and cognition in animal models.
Nature Aging
In Vitro Study
Urinary Nanoprobe Detects Therapy-Induced Senescence in Lung Cancer, Fibrosis
A new injectable albumin-based nanoprobe allows noninvasive, longitudinal monitoring of cellular senescence burden via urine testing.
Nature aging
Cohort Study
Uterine and Vaginal Tissues Show Abrupt Aging Shifts at Menopause
Multimodal analysis of seven reproductive organs reveals that while ovaries age gradually, the uterus undergoes rapid molecular remodeling.
Nature Aging
Mendelian Randomization Study
Beta-1 Blockers May Reduce Vascular Dementia Risk in Genetic Analysis
A Mendelian randomization study suggests beta-1 adrenergic antagonism protects white matter, while ACE inhibition may increase risk.