Spatial Proteomics Identifies Plaque-Associated Microglia in Alzheimer's Brains
A new imaging technology reveals a specific microglial subpopulation linked to dense amyloid-beta plaques in human Alzheimer's disease.
Axonic Spines on Axon Initial Segment Initiate Action Potentials, Route Information
A new study in mice identifies axonic spines as a mechanism for precise action potential generation and directed neural circuit communication.
Autism Subtypes Linked to Distinct Brain Connectivity and Biological Pathways
A cross-species neuroimaging study identifies two replicable autism subtypes with specific functional connectivity patterns and biological underpinnin
ALS Subtypes Show Distinct Immune Remodeling, Linking Blood Changes to Spinal Cord Damage
A new study details specific immune cell dynamics and molecular programs in ALS, revealing distinct patterns across disease subtypes.
Cerebellar Disinhibitory Circuit Controls Motor Learning Signals
New research in mice reveals how synchronized climbing fiber activity selectively gates error signals to enable adaptive motor learning.
Intracranial Stimulation Prevents Attentional Lapses in Children
A new study identifies a real-time neural signature for attentional control, enabling targeted intervention to improve attention shifts.
Macaque V1 Neuron Activity Links Internal States to Reaction Time, Perceptual Choice
New research in macaque monkeys reveals how primary visual cortex neuron membrane potential dynamically influences visual task performance.
Hippocampal Ripples Coordinate Cortical Planning Sequences in Epilepsy Patients
High-resolution intracranial recordings show that hippocampal ripples and neural replay drive the assembly of complex cognitive solutions.
Abdominal Contractions Drive Brain Motion and Fluid Clearance in Mice
A hydraulic link between the abdomen and cranium suggests physical activity mechanically facilitates interstitial fluid drainage.
Shared Mitochondrial Pathways Identified Across 23 Neurodevelopmental Risk Genes
Researchers used CRISPR to map how diverse genetic mutations converge on common molecular targets, allowing for drug testing in animal models.
Early Dopamine Loss Drives Memory Deficits in Alzheimer's Mouse Model
Dysfunction in dopamine neurons projecting to the lateral entorhinal cortex precedes neurodegeneration and impairs associative memory.
Grammatical Boundaries Limit Word Prediction Precision in the Human Brain
Neural responses to word unpredictability decrease at major phrase boundaries, suggesting language processing prioritizes structure over raw statistic