Hong Kong Genome Project Identifies Population-Specific Genetic Variants, Informs Prescriptions
A large-scale genomic initiative in the Chinese population reveals diagnostic rates for rare diseases and pharmacogenomic insights.
Favipiravir Safe, Well-Tolerated for Mild-to-Moderate Lassa Fever
A phase 2 trial in Nigeria provides pharmacokinetic data and supports favipiravir as an alternative to ribavirin for Lassa fever.
Multimodal AI System Matches Clinicians in Simulated Telehealth Diagnostics
A new AI system, multimodal AMIE, integrates diverse data types to achieve high diagnostic accuracy and conversational quality in simulated telehealth
Abatacept Reduces Rheumatoid Arthritis Progression in Seropositive Palindromic Rheumatism
A randomized trial indicates abatacept significantly lowers the risk of developing rheumatoid arthritis compared to hydroxychloroquine over two years.
TES Criteria Show Low Accuracy for CTE-NC Diagnosis
A study of 1,038 brain bank cases reveals that traumatic encephalopathy syndrome criteria poorly predict postmortem chronic traumatic encephalopathy.
Low-Dose Digoxin Fails to Reduce Heart Failure Events in Randomized Trial
A study of 1,001 patients found targeting low serum concentrations did not significantly lower mortality or urgent hospital visits.
CDR132L Fails to Improve Ventricular Volume After Myocardial Infarction
A phase 2 trial of the microRNA-132 inhibitor CDR132L showed no significant benefit in structural or functional endpoints at six months.
PREVENT and SCORE2 Equations Accurately Predict Global Cardiovascular Risk
A validation study of 6.4 million people confirms these risk models perform well across North America, Europe, and Asia.
Oral Nicotinamide Mononucleotide Increases Platelets in Refractory Immune Thrombocytopenia
A phase 1/2 trial shows oral NMN modulates the CD38-NAD+ axis to improve platelet counts while preserving humoral immunity.
Clinical Models Improve Pediatric Referral Accuracy in Southeast Asia
New triage tools utilizing pulse oximetry and sTREM1 show higher sensitivity for severe febrile illness than current WHO standards.
Retinal Imaging AI Screens for Six Systemic Metabolic and Endocrine Diseases
A multitask framework identifies diabetes, hypertension, and osteoporosis from fundus photos, showing high negative predictive value in primary care.
All of Us Program Links 14 Years of Wearable Data to Clinical Records
A massive dataset connects Fitbit metrics from 59,000 participants to genomics and electronic health records for longitudinal research.