Estrogen Protects Female Mice From FGF23-Induced Cardiac Hypertrophy
Estrogen antagonizes fibroblast growth factor 23 signaling in mice, preventing uremic cardiomyopathy and extending survival in females.
Evolocumab Reduces First Cardiovascular Events in High-Risk Diabetes
In patients with diabetes and no known atherosclerosis, adding evolocumab to statins lowered the 5-year risk of major events by 2.1%.
Delayed Angiography Safe in Cardiac Arrest Without ST-Segment Elevation
Five-year COACT trial data show no survival difference between immediate and delayed coronary angiography for resuscitated patients.
Kappa Free Light Chain Index Distinguishes MS From Clinical Mimics
A multicenter study shows the KFLC-Index provides high diagnostic accuracy in separating MS from MOGAD and AQP4-NMOSD.
Digital Exercise and Interoceptive Training Lower Acute Depression Scores in Young Adults
A randomized trial found significant short-term symptom reduction, though benefits did not persist at one- or three-month follow-up.
Group CBT Reduces Hostile Attribution Bias in Young Adults With ASD Traits
A pilot study finds that targeting social cognitive distortions improves communication and quality of life through distinct pathways.
Balanced Transfusion Reduces Trauma Mortality After Six Red Cell Units
A 4,858-patient analysis identifies the specific volume thresholds where 1:1 plasma ratios significantly improve survival in hemorrhage.
Group Cognitive Therapy Reduces Negative Symptoms in Early Psychosis
A pilot trial shows rumination-focused therapy added to standard care significantly improves negative symptoms and repetitive thinking.
Oral Nicotinamide Mononucleotide Increases Platelets in Refractory Immune Thrombocytopenia
A phase 1/2 trial shows oral NMN modulates the CD38-NAD+ axis to improve platelet counts while preserving humoral immunity.
Iron Bioresorbable Scaffolds Match Metallic Stents for Late Lumen Loss at Two Years
A randomized trial in China finds iron-based scaffolds achieve similar vascular patency and flow to standard stents despite higher revascularization.
Air Pollution Not Linked to Amyotrophic Lateral Sclerosis Risk
A prospective study of 500,000 UK adults finds no association between long-term exposure to particulate matter or nitrogen oxides and ALS.
Tailored AI Tool Increases Preparedness for Total Joint Arthroplasty
A pilot study shows 75% of arthroplasty patients feel more prepared using a custom AI aid, though postoperative query resolution varies.