Betaine Reverses Placental Hypoxia and Growth Restriction in Mouse Model of Depression
High-dose betaine restores VEGF and BDNF signaling to improve placental vascularity and fetal weight in stressed mice.
Triplet Immunotherapy Shows Durable Response in Relapsed Hodgkin Lymphoma
Adding ipilimumab to nivolumab and brentuximab vedotin may improve long-term disease control for patients deferring stem cell transplant.
Strategic Site Selection Improves Minority Representation in Stent Trials
An analysis of 8,859 participants shows that geographic and site-specific factors predict minority enrollment but not female participation.
High-Dose Influenza Vaccine Linked to Lower Alzheimer Risk in Seniors
A retrospective cohort study of 164,797 adults finds high-dose vaccination reduces dementia risk more than standard-dose formulations.
Neuroimaging Model Distinguishes Functional Constipation Subtypes with 89% Accuracy
Machine learning analysis of brain structure and white matter tracts identifies comorbid anxiety and depression in chronic constipation.
Group Metacognitive Therapy Reduces Pediatric OCD Symptoms Despite Comorbidities
A naturalistic study of 37 youth shows an 81.1% response rate and significant symptom reduction across complex diagnostic profiles.
Biological Maturation Predicts Sex-Specific Injury Risk in Junior Tennis Athletes
Boys face the highest injury burden during their peak growth spurt, while girls are most vulnerable 18 months after reaching maturation.
APT-Sepsis Program Lowers Maternal Infection Mortality and Morbidity
A cluster-randomized trial of 431,394 women shows a 32% reduction in severe infection-related outcomes using a standardized care bundle.
Contrast-Enhanced MRI Improves Staging Accuracy in Early Rectal Cancer
A combined MRI model identifies Tis-T1 lesions more accurately than endorectal ultrasound, aiding organ-sparing surgical decisions.
Cortical Stimulation Reduces Overactive Bladder Symptoms After Stroke
A randomized trial shows low-frequency rTMS improves urinary function and quality of life while lowering societal costs.
Immune Score Predicts Infection Risk in Multiple Myeloma
A three-factor immune profile identifies patients with a 60% infection incidence, offering a path to personalized prophylaxis.
High-Dose Yttrium-90 Resin Microspheres Improve Hepatocellular Carcinoma Response
A tumor-mean absorbed dose above 296.74 Gy predicts objective response, while doses exceeding 435.11 Gy consistently achieve complete response.