VTA-mPFC Dopamine Circuit Drives Stress-Induced Sleep Fragmentation in Mice
A new study in mice identifies specific dopaminergic neuron hyperexcitability as a key mechanism behind chronic stress-related sleep disruption.
Microsurgery Practice Patterns Shift with Innovation, Legislation Over Four Decades
A single-surgeon analysis of over 5,000 free flaps reveals how technical advances and health policy shape reconstructive trends.
Plasma p-tau217, Cognition, APOE4 Predict Alzheimer's Dementia Risk in SCD
A multimodal approach combining readily available biomarkers accurately identifies individuals with subjective cognitive decline at high risk for Alzh
Waveform-Derived 60-Second ROSC Definition Accurately Identifies Transient Events
A prospective validation study confirms a specific defibrillator waveform criterion reliably detects transient return of spontaneous circulation.
CBD's Pain Modulation Effects Vary by Opioid Dosing Timing in OUD Patients
A crossover study reveals cannabidiol's impact on pain sensitivity is dependent on whether opioid agonist treatment has been administered.
MMAE for cSDH: Resolution Trajectories and Functional Outcomes Quantified
A large multicenter study details the temporal patterns of hematoma reduction and functional recovery after middle meningeal artery embolization.
Plasma Proteins Predict Multiple Sclerosis Risk and Disease Severity
An integrated genetic-proteomic analysis identifies specific circulating proteins associated with MS risk and progression, offering potential…
Hippocampal Subfield Atrophy Links to Cognitive Decline in Healthy Aging
A study in healthy Indian adults identifies specific hippocampal subfield volume reductions in older age associated with poorer learning and memory.
AI Algorithm Continuously Monitors Inspiratory Muscle Effort, Patient-Ventilator Synchrony
A new AI algorithm offers a noninvasive, real-time method for assessing inspiratory muscle pressure and detecting dyssynchronies in mechanically…
ICP Monitoring Linked to Lower 30-Day Mortality in Kenyan Severe TBI Patients
A retrospective cohort study in a low- and middle-income country found intracranial pressure monitoring associated with reduced mortality.
Helicopter Transport Expands ECPR Access for Rural Refractory Cardiac Arrest
A HEMS-facilitated ECPR pathway safely extends advanced resuscitation to rural areas, maintaining neurologic outcomes comparable to ground transport.
ITBS Improves Fibromyalgia Symptoms; D-Cycloserine Augments Depressive Symptoms Only
A randomized trial found intermittent theta-burst stimulation significantly reduced fibromyalgia symptoms, but adjunctive D-Cycloserine only…