Double Sequential Defibrillation Implementation Shows No Survival Benefit in New Zealand EMS
A retrospective cohort study found no improvement in return of spontaneous circulation or 30-day survival after DSD introduction.
Autologous Reconstruction Reduces Failure Rates After Breast-Conserving Therapy
For patients with prior breast-conserving therapy, autologous reconstruction demonstrates significantly lower failure rates compared…
Bicarbonate Reduces Renal Replacement Therapy in Critically Ill Adults
A meta-analysis of four randomized controlled trials indicates sodium bicarbonate significantly lowers the need for renal replacement therapy.
Sickle Cell Trait Not Linked to Overall Mortality or Cardiovascular Disease
A large UK Biobank study finds sickle cell trait does not increase all-cause death or cardiovascular events, but associates with diabetes, kidney…
ATF2 Phosphorylation Drives Neuronal Apoptosis in Neurodegenerative Disease Models
A genome-wide screen identifies a specific molecular cascade involving ATF2 phosphorylation as a core driver of neuronal cell death.
Plantar Agraphesthesia Signals Lower Limb Cortical Sensory Loss in Corticobasal Syndrome
A case report details how plantar agraphesthesia can indicate cortical sensory deficits in the lower limb, even without hand involvement.
Successful HSCT Slows Brain Volume Loss in Adults With Sickle Cell Disease
A cohort study indicates that successful hematopoietic stem cell transplant is associated with preserved brain volume in adults with SCD.
Plain X-rays and Physical Exam Reliably Screen Pediatric Thoracolumbar Injuries
A multicenter study suggests dedicated spinal X-rays and physical exam can reduce unnecessary CT scans in children with potential spinal trauma.
Maternal Microbial Exposure Confers Intergenerational Stress Resilience in Male Mouse Offspring
Maternal administration of a heat-killed bacterium protected male offspring from chronic stress effects, potentially via microbiome changes.
Imdusiran Demonstrates Favorable Safety Profile in Early Hepatitis B Trial
A phase 1a/b study of the siRNA imdusiran shows it is well tolerated in healthy individuals and chronic hepatitis B patients.
Brazilian Study Pinpoints Persistent Critical Illness Onset at ICU Day 15
A large cohort study in Brazil identifies the transition to persistent critical illness at 15 days, impacting resource utilization.
TP53 and 5q Deletion Drive AML-CK Aneuploidy, Create BCL2 Vulnerability
A new study identifies the genetic drivers of complex karyotype acute myeloid leukemia and a targetable BCL2-dependent vulnerability.