Nurse-Led School CPR Program Multiplies Community Training Reach
Students using low-cost manikins trained an average of 2.4 family members, significantly expanding the pool of potential bystanders.
POT1 Mutations Drive Lymphoid Malignancy Through Ultralong Telomeres
Pathogenic POT1 variants increase lymphoma risk eightfold by extending cellular longevity and promoting age-dependent clonal expansion.
Transradial Access Does Not Increase Radiation in Aneurysm Treatment
A comparative study finds no significant difference in radiation dose between radial and femoral routes for endovascular repair.
Subthalamic Signal Propagation Predicts Parkinsonian Motor State
Movement-related high-frequency oscillations propagate along the inferior-superior axis, correlating with levodopa response.
Neurosurgeons Disagree on Resectability in Recurrent Glioblastoma Trial
A post-hoc analysis reveals low inter-rater agreement on surgical feasibility and no link between surgeon consensus and survival.
Small Vessel Disease Explains Reduced Thrombectomy Benefit in Older Patients
A secondary analysis of the RESILIENT trial finds that CT markers of brain frailty, not age alone, predict poor functional outcomes.
Low-Dose Digoxin Fails to Reduce Heart Failure Events in Randomized Trial
A study of 1,001 patients found targeting low serum concentrations did not significantly lower mortality or urgent hospital visits.
Early Magnesium Sulfate Linked to Lower Mortality in Pneumonia
A retrospective analysis of 9,203 ICU patients suggests early intravenous magnesium may reduce 30-day mortality risk by 16 percent.
Resident Response Vehicles Increase Exposure to High-Acuity Prehospital Care
A five-year study shows dedicated field vehicles provide residents with over 1,300 cardiac arrests and 2,000 medical control consults.
ACL Reconstruction Triples 20-Year Risk of Knee Arthroplasty
A study of 135,881 patients shows a 2.44% absolute risk of knee replacement two decades after surgery, rising with meniscal involvement.
Quality Improvement Shortens Time to Antibiotics in Pediatric Intestinal Failure
Multidisciplinary interventions reduced median cephalosporin delivery time by 58% for children with suspected central line infections.
Glofitamab Shows High Response Rates in Refractory Aggressive B-Cell Lymphoma
Real-world data link baseline CD4+ effector T cells and early CD8+ expansion to improved outcomes with bispecific antibody therapy.