CSF Tau Biomarkers Associate With Cognitive Impairment in ALS
Elevated cerebrospinal fluid tau levels correlate with cognitive deficits in ALS, though postmortem TDP-43 burden remains a stronger driver.
Dihydroartemisinin-Piperaquine Reduces Early Plasmodium vivax Recurrence Compared With Chloroquine
A randomized trial in Brazil shows dihydroartemisinin-piperaquine effectively prevents early malaria recurrence when primaquine is delayed.
Validated 33-Item Instrument Quantifies Patient Misconceptions Regarding Hospice Care
The Hospice Perceptions Instrument identifies specific barriers to enrollment, including myths about eligibility and service quality.
Early Cystography After Bladder Repair Reduces Catheter Time and Infections
Imaging within seven days of traumatic bladder repair safely shortens catheterization and lowers infection rates without missing leaks.
Dementia With Lewy Bodies Incidence Rises Sharply After Age 65
A meta-analysis of population-based studies reveals significant age and sex disparities in dementia with Lewy bodies epidemiology.
Single Sigmoidoscopy Reduces Male Colorectal Cancer Death at 23 Years
A Norwegian trial shows a single screening sigmoidoscopy provides long-term protection for men, but mortality benefits are absent in women.
Beti-cel Gene Therapy Sustains Transfusion Independence for Up to Ten Years
Long-term data show 90.2% of phase 3 patients achieved transfusion independence with stable hemoglobin and improved iron homeostasis.
Palliative Care Reduces Hospital Death Risk in Multiple Sclerosis
A large cohort study finds neurology oversight drops sharply before death, while rural patients face higher hospital mortality rates.
Tenecteplase Before Thrombectomy Does Not Improve Late-Window Stroke Outcomes
A phase 3 trial in patients with proximal MCA occlusions found no functional benefit to adding tenecteplase between 4.5 and 24 hours.
Nuclear Membrane Disruption Precedes Cytoplasmic Tau in Anti-IgLON5 Disease
Autopsy and in vitro data show that antibody binding triggers nuclear invaginations and serine 422 phosphorylation before tau aggregates.
Comorbidity Drives Genetic Overlap Between Anxiety and Major Depression
Excluding comorbid cases reveals that isolated anxiety and depression are more genetically distinct than previously recognized.
Digoxin Reduces Heart Failure Risk in Rheumatic Heart Disease
A randomized trial in India shows low-dose digoxin decreases the composite risk of death or worsening heart failure by 18 percent.