Evolocumab Reduces First Cardiovascular Events in High-Risk Diabetes
In patients with diabetes and no known atherosclerosis, adding evolocumab to statins lowered the 5-year risk of major events by 2.1%.
Cumulative Lead Exposure Linked to 3.5 Million Annual Cardiovascular Deaths
A meta-regression of NHANES data identifies bone lead levels as a major independent risk factor for global cardiovascular mortality.
Middle Meningeal Artery Embolization Reduces Subdural Hematoma Recurrence
Adjunctive embolization after surgery lowered symptomatic recurrence from 28% to 4.3% in a randomized trial of 186 patients.
Systematic Protocols Identify and Treat True Resistant Hypertension
True resistant hypertension affects 10% of treated patients and carries a 10.3% absolute risk increase in cardiovascular death.
Interdisciplinary Whole Health Teams Improve Chronic Pain Function Over Standard Care
A randomized trial of 764 veterans shows that value-aligned team care reduces pain interference more than group therapy or usual care.
Conduction System Pacing Reduces Hospitalization and Improves Ejection Fraction
New data suggest direct stimulation of the His bundle or left bundle branch improves outcomes over traditional biventricular pacing.
Symptom-Based Dosing Reduces Discharge Time in Neonatal Opioid Withdrawal
A cluster randomized trial shows symptom-based dosing shortens medical readiness for discharge when paired with the Eat, Sleep, Console model.
Tucidinostat Improves Event-Free Survival in Double-Expressor B-Cell Lymphoma
Adding a histone deacetylase inhibitor to R-CHOP increases complete response rates and reduces progression risk in high-risk patients.
Adding Tobramycin to Vancomycin Powder Does Not Reduce Tibial Fracture Infections
A randomized trial of 1528 patients shows dual intrawound antibiotic powder offers no benefit over vancomycin alone in high-risk fractures.
Severe Childhood Malaria Impairs Cognition Up to 15 Years Later
Ugandan children who survive cerebral malaria or severe malarial anemia show persistent cognitive and math deficits up to 15 years later.
Endometrial Cancer Mortality Rises as Management Shifts to Molecular Subtyping
Rising incidence in younger women and stark racial disparities in mortality underscore the need for early biopsy and tailored therapy.
Amoxicillin Equals Amoxicillin-Clavulanate for Acute Sinusitis
A nationwide cohort study shows standard amoxicillin is as effective as amoxicillin-clavulanate but avoids higher risks of C. difficile.