Four Clinical Trajectories Identify Distinct Outcomes in Acute Respiratory Failure
A multi-cohort analysis reveals predictable 14-day courses for patients with persistent acute hypoxemic respiratory failure.
Armchair Positioning Improves Oxygenation in Spontaneously Breathing ICU Patients
A randomized controlled trial found out-of-bed armchair positioning increased PaO2/FiO2 ratios compared to in-bed semi-recumbent positioning.
Standard Weight Formulas Overestimate Lung Size in Critically Ill Women
A large-scale analysis reveals that current tidal volume guidelines increase driving pressures and mortality risk for female patients.
Ketamine Shows No Sustained Hemodynamic Advantage Over Propofol During Intubation
A randomized trial in critically ill patients found that ketamine-induced blood pressure benefits were transient and did not improve survival.
Survival Improves for Leukemia Patients Requiring Mechanical Ventilation in the ICU
An individual participant data meta-analysis of 2003 patients shows declining mortality for ventilated adults with acute leukemia.
Continuous Probabilities Identify High-Risk Patients in Hypoinflammatory Respiratory Failure
Continuous modeling of IL-6 and sTNFR-1 reveals a 40% mortality risk in patients masked by binary inflammatory classification.
Non-Invasive Tools Estimate Intracranial Pressure When Invasive Monitoring Is Contraindicated
A review evaluates ultrasound and imaging techniques to detect intracranial hypertension in patients with coagulopathy or liver failure.
Heterogeneous Trial Endpoints Limit Evidence in Acute Kidney Injury
A review of 251 trials reveals inconsistent outcome definitions and measurements that hinder clinical application of renal research.
Low-Calorie Feeding Does Not Worsen Kidney Function in Shock
A post hoc analysis of 3,036 patients shows early restrictive diets are safe for the kidneys, even with preexisting dysfunction.
Bedside Score Predicts Successful Dialysis Discontinuation in ICU Patients
The UNDERSCORE tool uses six routine clinical variables to help physicians determine if critically ill patients can safely stay off dialysis.