PIEZO1 Variant Reclassification Identifies Three Clinical Phenotypes in DHS1
A new framework reclassifies 1,000 variants of uncertain significance and links specific protein domains to iron overload risk.
Open-Source AI Models Accurately Classify Pediatric Pneumonia on Radiographs
Large language models match physician adjudication of free-text reports, surpassing traditional machine learning in the emergency department.
Eleven-Protein Plasma Panel Identifies Parkinson’s Disease Across Four Cohorts
A machine learning model using 11 plasma proteins differentiated Parkinson’s from other neurological conditions with high accuracy.
Negative PCR Panel and Sputum Culture Rule Out Pneumonia Mimics
A prospective ICU study shows 91 percent specificity for non-infectious mimics when molecular and culture results are both negative.
Five-Gene Metabolic Signature Identifies Schizophrenia in Prefrontal Neurons
Researchers identified a diagnostic model based on fatty acid metabolism genes in specific neuronal subtypes with an AUC of 0.856.
App-Based Cognitive Tasks Increase Subclinical Mental Health Screening Accuracy to 91%
Combining objective neuropsychological metrics with self-reports identifies subclinical distress more accurately than subjective tools alone.
Revised Chinese DARS Validated for Multidimensional Anhedonia Assessment
A study of 788 psychiatric outpatients confirms a four-factor model for measuring reward deficits across diverse clinical domains.
EEG Topological Mapping Distinguishes Mild from Moderate Stroke with 86% Accuracy
Persistent homology identifies higher-order network disruptions in the prefrontal cortex to improve objective stroke severity assessment.
Coronary CT Angiography Misses Over One Third of Calcified Plaques
High-resolution non-contrast CT identifies small, low-density calcifications overlooked by standard angiography in nearly 9% of patients.
Vision-Enabled GPT Predicts Tube Thoracostomy Need in Spontaneous Pneumothorax
A retrospective study shows a generative model accurately measures apical depth and aligns with emergency department triage decisions.
Plasma p-tau217 Assays Show High Specificity for Alzheimer’s Diagnosis
Three diverse assay technologies demonstrate 100% specificity in differentiating Alzheimer’s from vascular and frontotemporal dementias.
AI Ensemble Matches Expert Consensus for Ultrasound Pneumothorax Detection
An explainable AI model achieved 100% sensitivity and specificity, reducing false positives compared to clinicians in M-mode imaging.