Rapid Susceptibility Testing Speeds Antibiotic Adjustments but Not Outcomes
While rapid testing accelerated antibiotic adjustments by 14 hours, it did not improve 30-day survival or reduce deleterious events.
Low-Calorie Feeding Does Not Worsen Kidney Function in Shock
A post hoc analysis of 3,036 patients shows early restrictive diets are safe for the kidneys, even with preexisting dysfunction.
Consensus Algorithm Standardizes Rural Air Medical Transport Triage
A multidisciplinary panel used a Delphi survey to identify 18 patient factors and 6 interventions that warrant helicopter transport.
Young Children Require Higher Benzodiazepine Doses for PICU Ventilation
A retrospective cohort study reveals that children under five receive significantly higher weight-adjusted doses of midazolam and lorazepam.
Bedside Score Predicts Successful Dialysis Discontinuation in ICU Patients
The UNDERSCORE tool uses six routine clinical variables to help physicians determine if critically ill patients can safely stay off dialysis.
Algorithm Predicts Mortality in Carbapenem-Resistant ICU Infections
A LightGBM model using routine clinical data accurately predicted 15-day mortality, highlighting coagulopathy and time to antibiotics.
Continuous Rocuronium Yields Modest Intracranial Pressure Reductions
A retrospective analysis reveals that continuous neuromuscular blockade lowers intracranial pressure by only 1 to 2 mm Hg in severe cases.
Limiting ICU Wrist Restraints Fails to Increase Delirium-Free Days
A restrictive wrist-strap protocol in mechanically ventilated adults did not improve delirium-free days or increase self-extubation risk.
12-Week Diet and Exercise Program Improves Post-ICU Physical Function
A 12-week regimen of exercise and protein supplementation significantly improves physical functioning in long-stay ICU survivors.
High-Flow Oxygen Lowers Intubation but Does Not Improve Survival
High-flow nasal cannula therapy reduces intubation rates in acute hypoxemic respiratory failure without altering 28-day mortality.
Prehospital Whole Blood Shows No Survival Benefit Over Component Therapy
A randomized trial of 616 trauma patients found prehospital whole blood did not reduce 24-hour mortality or massive transfusion needs.
Consensus Panel Identifies Systemic Barriers to Public Defibrillation
A RAND-UCLA consensus study of 46 international experts highlights poor residential coverage and lack of live registries as major hurdles.