Tezepelumab Reduces Exacerbations, Improves Lung Function in Diverse Severe Asthma Cohort
A real-world phase 4 study shows tezepelumab's effectiveness and safety across various severe asthma phenotypes and underrepresented patient groups.
Pre-SRS PD-1 Inhibitor Use Linked to Increased Neurological Deficits, Mortality
A multi-institutional study suggests administering PD-1 inhibitors before stereotactic radiosurgery in glioma patients may worsen outcomes.
DHODH Inhibition Targets Pyrimidine Synthesis in Chemo-Resistant B-ALL
A new study identifies dihydroorotate dehydrogenase (DHODH) as a metabolic vulnerability in B-ALL cells with active signaling.
POGO Score Shows Limited Diagnostic Value in Pediatric Videolaryngoscopy
A study of 904 pediatric intubations found the POGO score performed poorly in classifying difficult airways and predicting adverse events.
Astegolimab Reduces COPD Exacerbations in Broad Patient Population
A pooled analysis of two trials shows astegolimab significantly lowers moderate/severe exacerbation rates in patients with frequent COPD…
Acetate Attenuates Microglial Inflammation in Traumatic Brain Injury Model, Not Sepsis
Physiological doses of the gut metabolite acetate reduced inflammatory markers in an in vitro TBI model, but not in a sepsis model.
Platelet mTOR Pathway Drives Neuropathogenesis in Cerebral Malaria
A new study identifies the mechanistic target of rapamycin (mTOR) in platelets as a key mediator of brain injury in experimental cerebral malaria.
Four Clinical Trajectories Identify Distinct Outcomes in Acute Respiratory Failure
A multi-cohort analysis reveals predictable 14-day courses for patients with persistent acute hypoxemic respiratory failure.
Cervical Spinal Cord Injury Linked to Higher Depression Risk Than Lower-Level Injuries
A nationwide cohort study reveals patients with cervical SCI face a significantly elevated risk of depression compared to those with thoracic/lumbar.
Continuous EEG Enhances Detection of Post-Stroke Epilepsy Predictors
A retrospective study shows continuous EEG significantly improves identification of epileptiform activity and prediction of post-stroke epilepsy.
Nebulized Heparin Linked to Reduced Mortality, More Ventilation-Free Days in Respiratory Failure
A meta-analysis suggests nebulized unfractionated heparin improves survival and ventilation-free days in adults with acute respiratory failure…
Armchair Positioning Improves Oxygenation in Spontaneously Breathing ICU Patients
A randomized controlled trial found out-of-bed armchair positioning increased PaO2/FiO2 ratios compared to in-bed semi-recumbent positioning.