Prenatal Depression Does Not Alter Infant Oral Microbiome at Birth
A cohort study of 324 mother-infant pairs finds no link between maternal affective symptoms and neonatal microbial diversity or composition.
Plasma Tau and MRI Mismatch Identifies Rapid Alzheimer's Decline
Disproportionate brain atrophy relative to plasma ptau217 levels signals a vulnerable phenotype with faster cognitive loss and co-pathology.
All of Us Program Links 14 Years of Wearable Data to Clinical Records
A massive dataset connects Fitbit metrics from 59,000 participants to genomics and electronic health records for longitudinal research.
Mild Acute Kidney Injury Minimally Affects Long-Term Kidney Function Decline
A study of 1,603 patients finds that mild to moderate AKI causes a small permanent drop in GFR without accelerating annual decline.
Helicopter Transport Increases Survival for Specific High-Risk Trauma Phenotypes
Patients with low Glasgow Coma Scale scores and respiratory distress show the greatest benefit from air medical evacuation.
Age Over 75 Does Not Increase Facelift Complication Risk
A 10-year retrospective study of 541 patients shows no significant rise in major or minor complications for patients aged 76 and older.
UK Data Support Immunoglobulin-Free Maintenance After Liver Transplant
A retrospective study of 273 patients shows that long-term immunoglobulin does not reduce hepatitis B recurrence or improve survival.
Low CSF Amyloid-Beta Predicts Intracranial Hemorrhage in CAA Patients
Low levels of amyloid-beta 40 and 42 in cerebrospinal fluid are associated with a sevenfold increase in future symptomatic bleeding risk.
PD-1 Inhibitors Improve Survival in First-Line NK/T-Cell Lymphoma Treatment
Adding PD-1 inhibitors to asparaginase-based therapy reduces mortality risk by 45 percent in patients with high-risk extranodal disease.
Genetic Risk Factors Directly Link to Pediatric Suicidality Independent of Symptoms
Polygenic scores for internalizing and externalizing traits reveal direct and mediated pathways to suicidal ideation and attempts in youth.
Nipple Punch Grafts and Tattooing Improve Aesthetic Outcomes in Mastectomy
A pilot study shows combining punch grafts with 3D tattooing yields higher aesthetic ratings and fewer scars than traditional grafting.
Absence of Chest Pain Predicts Severe Pediatric Myocarditis Risk
A retrospective study identifies hemodynamic instability and elevated procalcitonin as key markers for ICU admission in children.