Reduced-Dose JAK Inhibitors Maintain Persistence in Low-Risk Rheumatoid Arthritis
A Japanese registry study of 1,135 patients finds reduced dosing effective for those with preserved renal function and few risk factors.
Nasoalveolar Molding Limits Early Lip Revisions in Cleft Patients Through Maturity
A 20-year follow-up shows only 3.7% of patients required lip revision before reaching skeletal maturity after nasoalveolar molding.
Robotic Groin Hernia Repair Shows Higher 5-Year Recurrence Than Laparoscopy
A Medicare cohort study finds robotic-assisted repair carries a 3.78% recurrence risk, exceeding both laparoscopic and open approaches.
Comparative Transcriptomics Map Shared Molecular Pathways in Parkinsonian Disorders
A large-scale analysis of 977 brain samples identifies core failures in protein homeostasis and mitochondrial metabolism across syndromes.
Intravenous Tocilizumab Stabilizes Severe Pediatric Neuroinflammation Within 72 Hours
A retrospective study shows rapid clinical improvement and intracranial pressure reduction in children with refractory CNS inflammation.
Dorsal Preservation Shows Early Aesthetic Gains Over Conventional Rhinoplasty
A seven-year cohort study finds dorsal preservation improves six-month cosmetic scores, though long-term outcomes converge by one year.
Patient-Provided Video Footage Influences Pediatric Trauma Management Decisions
Reviewing video of injury mechanisms altered imaging and specialist consultation plans in over half of pediatric emergency cases.
Maintenance Pembrolizumab and Radiotherapy Improve Outcomes in Oligometastatic Renal Cell Carcinoma
A pooled analysis of phase 2 trials shows a hazard ratio of 0.57 for progression-free survival when adding immunotherapy to local therapy.
Gut Microbiome Signatures Improve Nasopharyngeal Carcinoma Detection
Metagenomic analysis identifies microbial markers that enhance the diagnostic accuracy of Epstein-Barr virus DNA for nasopharyngeal cancer.
Outpatient Oncology Records Lack Goals-of-Care Documentation for Most Older Adults
A retrospective study of 7,743 patients found that only 43% had documented goals-of-care conversations in their electronic health records.
Patellar Resurfacing Shows No Clinical Advantage in Propensity-Matched TKA Analysis
A large-scale study finds equivalent patient-reported outcomes and complication rates whether or not the patella is resurfaced.
Prenatal Depression Does Not Alter Infant Oral Microbiome at Birth
A cohort study of 324 mother-infant pairs finds no link between maternal affective symptoms and neonatal microbial diversity or composition.