Daraxonrasib Shows Activity in Previously Treated RAS-Mutated Pancreatic Cancer
A phase 1-2 study finds that a multiselective RAS inhibitor achieves objective responses and manageable toxicity in advanced disease.
Benign Calcifications Drive False-Positive AI Risk Scores in Mammography
A study of 130,031 mammograms reveals that amorphous calcifications often trigger high AI risk scores in non-cancerous cases.
Memory Deficits Precede Processing Speed Decline in Modern Multiple Sclerosis Care
A large cohort study suggests the traditional speed-centric model of cognitive impairment no longer applies to most current patients.
Gaucher Disease Type 1 Carries 12% Parkinson Risk by Age 80
A registry study of 1,618 patients finds over 20% develop parkinsonian symptoms or dementia with Lewy bodies by the eighth decade.
Stop-Short Technique Doubles Carotid Dissection Risk During TCAR
A registry analysis of 25,346 patients identifies procedural and demographic factors linked to intraoperative arterial injury.
Residency Milestones Predict Performance in Vascular Surgery Fellowship
A national study of 266 trainees finds that general surgery competency ratings correlate with first-year fellowship achievement.
Lower Rugby Tackle Height Reduces Ball-Carrier Risk but May Increase Tackler Impacts
A simulation of 23,081 tackles suggests that mandating lower hits redistributes neurotrauma risk between players rather than eliminating it.
Late-Onset MS Patients Receive Fewer High-Efficacy Therapies Despite Similar Disease Severity
A French registry study of 36,148 patients shows those diagnosed after age 50 are less likely to initiate or escalate treatment.
Enhanced Recovery Protocols Reduce Length of Stay in Frail Bypass Patients
A retrospective study shows high frailty does not impede protocol compliance and significantly lowers reintervention rates and hospital stay.
Photon Counting CT Maintains TAVR Image Quality with 37.5% Less Contrast
Low-energy virtual monoenergetic reconstructions compensate for reduced iodine volume, improving signal-to-noise ratios in TAVR planning.
Glutamate Receptor Gene Variants Linked to Comorbid ADHD and Autism
Large-scale genomic analysis identifies specific structural variants in glutamatergic networks that distinguish complex ADHD phenotypes.
Peer Feedback Reduces Chest Pain Admissions Among High-Admitting Clinicians
Individualized performance data combined with protocols lowered admission rates by up to 14.3 percent for high-utilizing physicians.