Intracranial Recording Maps Immediate and Sustained Effects of Brain Stimulation
Direct neural recordings in humans and primates reveal that magnetic pulses trigger cellular excitation in 2 milliseconds.
Autologous Mesenchymal Cells Reduce Neuroinflammation in Chronic Brain Injury
A Phase 1/2a trial shows intravenous stromal cells improve white matter integrity and reduce immune cell density in the chronic TBI brain.
Memory Deficits Precede Processing Speed Decline in Modern Multiple Sclerosis Care
A large cohort study suggests the traditional speed-centric model of cognitive impairment no longer applies to most current patients.
Glutamate Receptor Gene Variants Linked to Comorbid ADHD and Autism
Large-scale genomic analysis identifies specific structural variants in glutamatergic networks that distinguish complex ADHD phenotypes.
Clinical Milestones Predict Survival in Multiple System Atrophy
A study of 555 patients identifies late-stage markers and time-dependent prognostic factors to guide clinical management.
Plasma Tau and MRI Mismatch Identifies Rapid Alzheimer's Decline
Disproportionate brain atrophy relative to plasma ptau217 levels signals a vulnerable phenotype with faster cognitive loss and co-pathology.
Epilepsy Patients Show Amyloid-Independent Tau Deposition Linked to Clinical Severity
PET imaging and proteomics reveal that chronic epilepsy correlates with widespread tau accumulation and accelerated multi-organ aging.
Guillain-Barré Syndrome Incidence Declined 9% in Japan During the Pandemic
A nationwide survey reveals a shift toward demyelinating subtypes and older patients as conventional infectious triggers decreased.
DMN Connectivity Predicts Amyloid Accumulation and Clinical Decline in Alzheimer’s
Longitudinal imaging shows functional network disruptions precede detectable amyloid plaques and signal future cognitive impairment.
GABAA Gain-of-Function Mutation Triggers Seizures via Interneuron Network Collapse in Mice
A study of the GABRB3 p.(Glu77Lys) variant reveals how enhanced inhibitory signaling paradoxically drives cortical hyperexcitability.
Eleven-Protein Plasma Panel Identifies Parkinson’s Disease Across Four Cohorts
A machine learning model using 11 plasma proteins differentiated Parkinson’s from other neurological conditions with high accuracy.
Lower Tau PET Sensitivity in Older Men Reflects Reduced Tangle Density
Flortaucipir PET sensitivity for advanced Alzheimer pathology drops to 42% in patients over 83, mirroring lower biological tangle burdens.