Nuclear Membrane Disruption Precedes Cytoplasmic Tau in Anti-IgLON5 Disease
Autopsy and in vitro data show that antibody binding triggers nuclear invaginations and serine 422 phosphorylation before tau aggregates.
Subthalamic Signal Propagation Predicts Parkinsonian Motor State
Movement-related high-frequency oscillations propagate along the inferior-superior axis, correlating with levodopa response.
Long-Read Sequencing Resolves Atypical Facioscapulohumeral Dystrophy Loci
High-resolution sequencing identifies complex structural variants in the 1% to 2% of patients who lack standard genetic markers.
Selective HDAC6 Inhibition Restores Axonal Transport in Preclinical ALS Models
A brain-penetrant small molecule improves motor function and reduces TDP-43 pathology in animal and human cellular models of neurodegeneration.
Amygdala Damage Does Not Impair Intrinsic Motivation to Empathize
Patients with focal amygdala lesions maintain a normal drive to engage in empathic encounters despite deficits in emotional recognition.
Chronic Stroke Survivors Retain Motivational Drive Despite Impaired Reward Learning
A study of 40 patients shows that while stroke slows belief updating, the ability to speed up movements for rewards remains intact.
SSPOP Gene Mutations Linked to Pediatric Epilepsy and Developmental Delay
Researchers identify pathogenic variants in a presumed pseudogene, expanding the diagnostic landscape for unexplained seizure disorders.
Skin Biopsies Differentiate Body-First and Brain-First Parkinson’s Disease
Cutaneous alpha-synuclein patterns and seeding kinetics identify distinct pathological origins in Parkinson’s disease subtypes.
Apathy Mechanisms Differ Between Alzheimer's and Parkinson's Disease
Computational modeling reveals distinct effort-sensitivity profiles and neural signatures for motivational loss across neurodegenerative types.
SPAST Variant Mapping Predicts Disease Trajectory in Spastic Paraplegia Type 4
Genetic essentiality mapping and neurofilament levels differentiate rapid functional decline from moderate biphasic progression in SPG4.
Medial Temporal Lesions Impair Memory Precision Rather Than Capacity
Post-surgical data from 40 epilepsy patients show hippocampal damage increases recall variability without reducing the total items retained.
Identical EEG Bursts Signal Severe Loss of Brain Network Complexity
A multi-model study identifies identical burst suppression as a default state of simplified excitatory networks in irreversible coma.