Continuous EEG Enhances Detection of Post-Stroke Epilepsy Predictors
A retrospective study shows continuous EEG significantly improves identification of epileptiform activity and prediction of post-stroke epilepsy.
Long-Duration Levodopa Response Distinguishes Parkinson's, Predicts Outcomes
A study details how sustained levodopa motor improvement helps differentiate parkinsonian syndromes and offers prognostic insights for PD.
Parkinson's Dementia Risk Lower, Later Than Prior Estimates
New data from the Parkinson's Progression Markers Initiative refines understanding of cognitive decline prevalence and progression.
CSF Tau Biomarkers Associate With Cognitive Impairment in ALS
Elevated cerebrospinal fluid tau levels correlate with cognitive deficits in ALS, though postmortem TDP-43 burden remains a stronger driver.
Small Vessel Disease Explains Reduced Thrombectomy Benefit in Older Patients
A secondary analysis of the RESILIENT trial finds that CT markers of brain frailty, not age alone, predict poor functional outcomes.
Auditory Slow-Wave Stimulation Reduces Axonal Damage in Rat Brain Injury Model
Closed-loop acoustic triggers during deep sleep preserved white matter integrity and cognitive function in a preclinical study of TBI.
Rapid Inter-Temporal Seizure Spread Linked to Poor Surgical Outcomes
Deep learning analysis of 275 seizures shows that extensive cortical involvement and rapid propagation correlate with surgical failure.
Synuclein Status Shows Limited Correlation With Brain Microstructure in Early Parkinson's
A study of 462 patients finds that positive alpha-synuclein assays do not reflect widespread neurodegeneration on diffusion MRI.
Multimorbidity Linked to Alzheimer's Biomarkers in Dementia-Free Adults
Cumulative chronic disease burden correlates with amyloid deposition, neurodegeneration, and vascular injury before cognitive symptoms emerge.
Pre-Diagnostic Beta-Carotene Levels Linked to Lower ALS Risk in Women
A nested case-control study finds sex-specific associations between plasma antioxidant profiles and future amyotrophic lateral sclerosis.
Low CSF Amyloid-Beta Predicts Intracranial Hemorrhage in CAA Patients
Low levels of amyloid-beta 40 and 42 in cerebrospinal fluid are associated with a sevenfold increase in future symptomatic bleeding risk.
Stroke Etiology Does Not Alter Bridging Thrombolysis Efficacy
A meta-analysis of six trials finds no interaction between stroke cause and the benefit of thrombolysis before mechanical thrombectomy.