Erythroid FGF23 Directly Inhibits Red Cell Production in Mouse Models
Local fibroblast growth factor 23 signaling in the bone marrow impairs erythropoiesis through FGFR1 activation and mitochondrial dysfunction.
Hypothalamic Astrocytes Drive Dexmedetomidine Sedation via Calcium Signaling in Mice
Researchers identified a specific astrocytic pathway that modulates inhibitory GABA currents to facilitate pharmacological sedation.
Interferon-Gamma Drives Chronic Bone Marrow Damage After Doxorubicin in Mice
Targeting T-cell-driven inflammation may prevent long-term skeletal and hematopoietic defects observed in leukemia survivors.
Focused Ultrasound Reduces Alcohol Preference and Anxiety in Mice
Low-intensity focused ultrasound targeting the hippocampus mitigates neuronal degeneration and suppresses withdrawal symptoms in a mouse model.
Gut Permeability Triggers Atrial Fibrillation via JNK2 Activation in Mice
Intestinal barrier dysfunction releases cytokines that activate cardiac JNK2, driving the calcium leaks that sustain atrial arrhythmias.
Iron Deficiency Drives Dopaminergic Hypersensitivity in Rodent Restless Legs Model
A study in mice links brain iron deficiency to increased GABA release in the striatal-entopeduncular pathway, mimicking opioid withdrawal.
Macrophage PRMT9 Limits Myocardial Infarction Damage in Mice
Researchers found that PRMT9 triggers STAT1 degradation to suppress inflammation and reduce infarct size in experimental models.
Cajanine Reduces Anxiety and Fear Extinction Deficits in Female Mice
The compound modulates the ERβ/NF-κB pathway to alleviate neuroinflammation and behavioral symptoms in a sex-specific manner.
Intestinal Permeability Triggers Atrial Fibrillation via JNK2 Activation in Mice
Researchers identified a signaling axis where leaky gut-associated cytokines activate cardiac JNK2 to cause calcium-handling abnormalities.
Adolescent Nicotine Rewires Brain Circuitry to Boost Opioid Reward in Mice
Early nicotine exposure alters GABA signaling in the ventral tegmental area, amplifying the rewarding effects of morphine in adult mice.
Dopamine Blockade Attenuates Morphine Analgesia in Rat Hippocampus
Blocking D1 dopamine receptors in the dentate gyrus significantly reduces the pain-relieving effects of morphine in an animal model.
Hippocampus-Thalamus Circuit Drives Contextual Hyperactivity in PTSD Mouse Model
A specific glutamatergic pathway may be a therapeutic target for context-dependent arousal symptoms.