Prefrontal Gene Networks Predict Fentanyl Escalation in Rat Models
Researchers identified specific ion channel and synaptic signaling pathways in the prefrontal cortex linked to compulsive opioid intake.
Kratom Leaf Extract Alleviates Stress-Induced Bladder Dysfunction in Male Mice
Oral mitragynine reduces bladder pain, mast cell infiltration, and muscarinic hyperreactivity in a murine model of chronic stress.
SIRT5 Deficiency Drives Cardiac Fibrosis via Metabolic Shift in Mice
Loss of SIRT5 in cardiac fibroblasts triggers a glycolytic shift that accelerates heart failure, identifying a potential metabolic target.
Early Dopamine Loss Drives Memory Deficits in Alzheimer's Mouse Model
Dysfunction in dopamine neurons projecting to the lateral entorhinal cortex precedes neurodegeneration and impairs associative memory.
Social Stress Drives Sex-Specific Molecular Changes in Female Reward Circuitry
Mouse models and human data reveal that social withdrawal in females involves distinct gene expression patterns in the nucleus accumbens.
Hypoxia Preconditioning Increases Adipose Stem Cell Fusion Mass in Rats
Stabilizing hypoxia-inducible factor-1α with DMOG improves bone formation and tissue maturation in a posterolateral spinal fusion model.
IL-15 Receptor Deficiency Drives Depressive Behaviors via Microglial Synapse Pruning in Mice
Loss of IL-15RA signaling triggers prefrontal cortex synapse loss through the CX3CL1 pathway, offering a potential target for depression.
Systemic Inflammation Triggers Sex-Specific Social Proximity Changes in Mice
While both sexes show similar sickness behaviors, acute immune activation specifically reduces social distance in male mice.
Norepinephrine Drives Sleep-Dependent Astrocyte Volume Changes in Mouse Cortex
Astrocyte expansion during wakefulness reduces interstitial space and suppresses glymphatic flow via alpha-1 adrenergic signaling.
GABAA Gain-of-Function Mutation Triggers Seizures via Interneuron Network Collapse in Mice
A study of the GABRB3 p.(Glu77Lys) variant reveals how enhanced inhibitory signaling paradoxically drives cortical hyperexcitability.
Ketamine Increases Brain PDE4 Binding in Rats and Monkeys
Subanesthetic doses rapidly boost cAMP signaling, suggesting a molecular pathway for the drug's fast-acting antidepressant effects.
Lateral Septal PACAP Signaling Modulates Stress and Anxiety in Rodent Models
Localized neuropeptide activity in the lateral septum regulates the neuroendocrine response and shifts behavior toward passive coping.