Platelet mTOR Pathway Drives Neuropathogenesis in Cerebral Malaria
A new study identifies the mechanistic target of rapamycin (mTOR) in platelets as a key mediator of brain injury in experimental cerebral malaria.
Axonic Spines on Axon Initial Segment Initiate Action Potentials, Route Information
A new study in mice identifies axonic spines as a mechanism for precise action potential generation and directed neural circuit communication.
Social Rank Modulates Empathic Pain via ACC-NAcC Circuit in Mice
A specific glutamatergic pathway and molecular target influence empathic pain responses based on social hierarchy.
SSRIs Induce Spatially Distinct Molecular Changes in Dorsal Raphe Serotonin Neurons
A mouse study reveals how fluoxetine alters gene expression and neuropeptide levels in specific serotonergic subpopulations.
Autism Subtypes Linked to Distinct Brain Connectivity and Biological Pathways
A cross-species neuroimaging study identifies two replicable autism subtypes with specific functional connectivity patterns and biological underpinnin
Simvastatin Rescues Cognitive Impairment in Alzheimer's Model via Epigenetic and Synaptic Pathways
A preclinical study in mice identifies specific molecular mechanisms by which simvastatin may improve cognitive function in Alzheimer's disease.
SHANK3 Haploinsufficiency in Macaques Reveals Diverse Behavioral, Cognitive Phenotypes
A new macaque model of SHANK3 haploinsufficiency provides insights into Phelan-McDermid syndrome and potential biomarkers.
Alantolactone and Temozolomide Combination Targets Glioblastoma Stemness, Lipid Metabolism
Preclinical findings suggest alantolactone combined with temozolomide may overcome glioblastoma resistance by modulating the Hippo pathway.
Apelin Mediates Exercise's Antidepressant Effects via Hippocampal NMDA Receptors
A muscle-derived protein, apelin, links physical activity to improved mood and neuroplasticity through a specific brain signaling pathway.
Fentanyl Differentially Modulates Dopamine Patterns, Impairing Reward Seeking in Mice
Acute fentanyl administration simultaneously increases tonic dopamine while reducing phasic dopamine responses to non-drug reward cues.
Tfr2 Essential for Acute Hepcidin Induction in Tfr1-Deficient Mouse Hepatocytes
A murine study reveals that transferrin receptor 2 and HFE must cooperate to trigger hepcidin during rapid iron fluctuations.
Prefrontal GABAergic Synaptic Plasticity Regulates Cognitive Flexibility
A new study identifies a specific long-range inhibitory synaptic mechanism in the prefrontal cortex crucial for adapting to changing rules.