Macaque V1 Neuron Activity Links Internal States to Reaction Time, Perceptual Choice
New research in macaque monkeys reveals how primary visual cortex neuron membrane potential dynamically influences visual task performance.
Maternal Fasting in Mice Induces Schizophrenia-Related Phenotypes
A mouse model links transient fasting during early gestation to epigenetic changes and altered neural circuitry in offspring.
Extracorporeal Limb Perfusion Does Not Exacerbate Bleeding in Porcine Trauma Model
A study of Lower Extremity Extracorporeal Distal Revascularization shows stable clot integrity despite uncontrolled vascular injuries.
Galectin-3 Inhibition Prevents Excitatory Synapse Loss in Murine Neuroinflammation Models
Targeting microglial Galectin-3 preserves hippocampal gamma power and cognitive function by stopping the selective engulfment of synapses.
Auditory Slow-Wave Stimulation Reduces Axonal Damage in Rat Brain Injury Model
Closed-loop acoustic triggers during deep sleep preserved white matter integrity and cognitive function in a preclinical study of TBI.
Arterial Netrin-4 Maintains Adult Sympathetic Neurons in Mice
Intracranial arteries provide a trophic niche that prevents age-related neuronal attrition through a non-inflammatory death pathway.
THC Disrupts Rat Fear Memory via Sex-Specific Microglial and Receptor Pathways
In male rats, THC requires microglial recruitment and dual receptor signaling, while female effects depend on the estrous cycle and CB1.
Nucleus Accumbens Dopamine Regulates Multi-Option Foraging Rates in Mice
A global learning rate in the nucleus accumbens core allows for rapid value integration across six concurrent choices in large arenas.
Interneuron Loss Fails to Amplify mTOR-Related Seizures in Mice
A two-hit model shows that hippocampal interneuron depletion triggers transient seizures but does not synergize with Pten mutations.
C1q-Mediated Synaptic Pruning Drives Postoperative Cognitive Decline in Murine Models
Surgical trauma triggers NF-κB signaling and C1q-dependent microglial phagocytosis of hippocampal synapses, leading to memory impairment.
Implantable Microdevices Map Chemotherapy Response in Pancreatic Cancer Mouse Models
Localized delivery of five chemotherapeutic agents via microdevices identifies drug-specific sensitivity in patient-derived organoid tumors.
Sleep Loss Delays Rat Surgical Recovery via Epigenetic Opioid Receptor Suppression
REM sleep disturbance downregulates the TET1 enzyme, reducing mu-opioid receptor expression in the spinal cord and dorsal root ganglion.