POGO Score Shows Limited Diagnostic Value in Pediatric Videolaryngoscopy
A study of 904 pediatric intubations found the POGO score performed poorly in classifying difficult airways and predicting adverse events.
Heparin Dosing, ACT Monitoring Not Linked to Improved Outcomes After LEB
A large study suggests routine activated clotting time monitoring during lower extremity bypass may not improve patient outcomes.
Bupivacaine-Dexamethasone TAP Blocks Reduce LOS, Opioid Use in DIEP Flap Patients
A retrospective study suggests bupivacaine with dexamethasone improves early pain control and shortens hospital stay after DIEP flap breast reconstruc
Brepocitinib 30 mg Improves Dermatomyositis Symptoms and Reduces Glucocorticoid Need
A phase 3 trial shows that once-daily oral brepocitinib 30 mg significantly improves disease activity and allows for glucocorticoid tapering in adults
Patient-Level Adherence Drives Enhanced Recovery Benefits in Pediatric GI Surgery
A stepped-wedge trial shows that while site-level ERP implementation may not reduce length of stay, patient-level adherence does.
High Antiplatelet Resistance, Elevated von Willebrand Factor in Vascular Surgery Patients
A new study reveals a high prevalence of antiplatelet resistance, particularly to clopidogrel, and elevated von Willebrand factor in patients undergoi
Propofol Reduces Long-Term Water Contamination Compared to Sevoflurane
A modeling study finds sevoflurane leads to irreversible accumulation of trifluoroacetic acid while propofol residues remain biodegradable.
Low Cardiac Index During Hypotension Increases Acute Kidney Injury Risk
A study of 1,272 cardiac surgery patients finds that hypotension only correlates with renal injury when cardiac index falls below 2.
C1q-Mediated Synaptic Pruning Drives Postoperative Cognitive Decline in Murine Models
Surgical trauma triggers NF-κB signaling and C1q-dependent microglial phagocytosis of hippocampal synapses, leading to memory impairment.
Prophylactic Antiemetics Fail to Reduce Opioid-Induced Nausea in Prehospital Trauma
A prospective study of 205 HEMS patients shows no benefit for routine intravenous ondansetron or isopropanol aromatherapy.
Standard Weight Formulas Overestimate Lung Size in Critically Ill Women
A large-scale analysis reveals that current tidal volume guidelines increase driving pressures and mortality risk for female patients.
Identical EEG Bursts Signal Severe Loss of Brain Network Complexity
A multi-model study identifies identical burst suppression as a default state of simplified excitatory networks in irreversible coma.