The Briefing
Continuous newsroom coverage of clinically relevant evidence — newest first.
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Plasma GFAP and NfL Predict Long-Term Mortality in Older Adults
Elevated baseline levels of GFAP and NfL strongly correlate with future risk of all-cause, dementia, and cardiovascular death.
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Adhesions Drive Most Small Bowel Obstructions in the Virgin Abdomen
A retrospective study of 312 patients shows conservative management is feasible, with a 4.9% mortality rate in non-operative cases.
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Algorithm Predicts Parkinsonism Pathology From Clinical Symptoms
A machine learning tool trained on brain bank data uses 23 clinical parameters to accurately predict post-mortem pathology in parkinsonism.
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Inhibiting USP22 Halts Periodontitis-Linked Brain Inflammation in Mice
Knocking down the enzyme USP22 in mice prevents the periodontal pathogen P. gingivalis from degrading blood-brain barrier tight junctions.
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Women Face Worse Functional Recovery After Intensive Care EEG
Despite similar acute management and mortality, critically ill women are half as likely as men to achieve favorable long-term recovery.
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Baseline Breathing Patterns Predict Post-Seizure Hypoxemia Severity
Measuring respiratory variability between seizures may help identify epilepsy patients at highest risk for severe oxygen desaturation.
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Brain Imaging Maps How Deep Brain Stimulation Alters Parkinson's Circuits
Extensive functional MRI data from 14 patients reveals that cortical connectivity patterns can predict clinical outcomes of stimulation.
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Structured Diagnostic Approach Guides Management of Chronic Diarrhea
A comprehensive clinical review details specific red flags for endoscopic evaluation and outlines empiric therapies that improve symptoms.
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Social Isolation Linked to Mood Episodes in Youth Bipolar Disorder
A scoping review of 522 patients identifies loneliness as a marker of poor psychosocial function and altered neural social processing.
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Decision Tool Reduces Antidepressant Discontinuation in Depression
A web-based system personalizing antidepressant selection kept more patients on therapy at 8 weeks and improved symptoms at 24 weeks.
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Glutamate Levels Link to EEG Hyperexcitability in Borderline Personality Disorder
Metabolic imaging reveals that glutamate ratios in the nucleus accumbens and cingulate cortex correlate with neural instability markers.
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Obinutuzumab Shows High Efficacy in Active Systemic Lupus Erythematosus
A phase 3 trial shows the anti-CD20 antibody obinutuzumab significantly improves clinical responses and reduces flares in active lupus.
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Pimicotinib Yields 54% Response in Tenosynovial Giant Cell Tumors
The selective inhibitor pimicotinib demonstrates high efficacy for unresectable joint tumors while avoiding severe hepatotoxicity.
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Zorevunersen Cuts Convulsive Seizures in Children With Dravet Syndrome
The investigational antisense therapy reduced convulsive-seizure frequency by up to 90.91% and improved adaptive behavior over 36 months.
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Seven Hours of Sleep Maximizes Depression Risk Reduction in Older Adults
A national cross-sectional study reveals a non-linear relationship where the mental health benefits of sleep attenuate after seven hours.
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ADHD Linked to Attenuated Rightward Structural Asymmetry in Children
MRI data reveal that reduced right-hemisphere dominance in frontal and striatal regions correlates with impaired attention and timing.
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Finerenone Reduces Albuminuria in Type 1 Diabetes and CKD
A phase 3 trial shows the mineralocorticoid receptor antagonist finerenone safely lowers albuminuria in adults with type 1 diabetes.
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Baxdrostat Reduces 24-Hour Blood Pressure in Resistant Hypertension
A phase 3 trial shows the selective aldosterone synthase inhibitor baxdrostat reduces systolic blood pressure by 14 mm Hg versus placebo.
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Neoadjuvant GOLP Doubles Event-Free Survival in Cholangiocarcinoma
Administering the GOLP regimen before surgery extends median event-free survival to 18 months in high-risk intrahepatic cholangiocarcinoma.
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LGBTQ+ EMS Clinicians Balance Professional Identity and Disclosure
A qualitative analysis reveals how LGBTQ+ prehospital clinicians navigate workplace disclosure while prioritizing their clinical skills.
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Sleep Under 6.7 Hours Linked to Depression in Opioid Users
A U-shaped dose-response curve reveals that insufficient sleep increases depression risk by 60% among adults taking prescription opioids.
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Lab and Point-of-Care Electrolyte Tests Diverge in 10% of ICU Cases
A prospective study reveals that central lab and point-of-care sodium and potassium measurements are not interchangeable in critical care.
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Digital Dyadic Interventions Improve Cognition and Reduce Caregiver Burden
A review of 38 studies finds digital tools like mobile apps and remote platforms enhance patient cognition and ease caregiver burden.
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Real-World CBT Improves Distress but Not Pain in Functional Neurological Disorder
Routine clinical data from 234 adults shows cognitive behavioral therapy significantly reduces psychological distress but not physical pain.