The Briefing
Continuous newsroom coverage of clinically relevant evidence — newest first.
Earlier
24 stories-
Erythroid FGF23 Directly Inhibits Red Cell Production in Mouse Models
Local fibroblast growth factor 23 signaling in the bone marrow impairs erythropoiesis through FGFR1 activation and mitochondrial dysfunction.
-
Mosunetuzumab and Polatuzumab Vedotin Show High Response in Refractory MCL
A phase 2 trial reports a 78.6% complete response rate in patients with mantle cell lymphoma after Bruton tyrosine kinase inhibitor failure.
-
Childhood Cognitive Control Predicts Adult Tic Remission and Income
Early executive function measures in children with Tourette syndrome correlate with clinical and socioeconomic success 11 years later.
-
LDTM Transfer Achieves 91% Return-to-Work Rate for Subscapularis Tears
A retrospective study of 189 patients shows significant functional gains and a mean five-month return to employment after tendon transfer.
-
Standard Activity Guidelines Better Preserve Hippocampal Volume Than HIIT in Older Adults
A nine-year study finds that baseline fitness and moderate activity provide more durable neuroprotection than high-intensity training.
-
Eleven-Protein Plasma Panel Identifies Parkinson’s Disease Across Four Cohorts
A machine learning model using 11 plasma proteins differentiated Parkinson’s from other neurological conditions with high accuracy.
-
Hypothalamic Astrocytes Drive Dexmedetomidine Sedation via Calcium Signaling in Mice
Researchers identified a specific astrocytic pathway that modulates inhibitory GABA currents to facilitate pharmacological sedation.
-
Activity Modality and Social Context Alter Pediatric Brain Structure
A longitudinal study of 8,230 children links physical-social engagement to increased frontoparietal volume and lower psychiatric risk.
-
Prenatal Sterol-Inhibiting Drugs Linked to Increased Autism Risk
A study of 6 million births found that common medications disrupting cholesterol synthesis increase autism risk in a dose-dependent manner.
-
Dexmedetomidine Linked to Lower Mortality in ICU Patients With Delirium
A retrospective analysis of two large databases shows reduced in-hospital and one-year mortality for delirious patients given the sedative.
-
Subanesthetic Ketamine Improves Depressive Symptoms in Critically Ill Adults
A retrospective study finds three days of low-dose ketamine reduces sadness in ICU patients with minimal hemodynamic impact.
-
Sonorheometry Reliably Excludes Coagulopathy During Initial Trauma Resuscitation
A multicenter study validates bedside sonorheometry for rapid exclusion of trauma-induced coagulopathy with high negative predictive values.
-
Negative PCR Panel and Sputum Culture Rule Out Pneumonia Mimics
A prospective ICU study shows 91 percent specificity for non-infectious mimics when molecular and culture results are both negative.
-
Experts Define 50 Hospital-Based Criteria for Pediatric Critical Illness
A consensus-based framework provides standardized metrics to identify high-risk children and benchmark emergency medical services performance.
-
Early Tracheostomy Increases Discharge to Home Rates in Selected ICU Patients
A retrospective study of 205 patients shows that tracheostomy within 10 days reduces ventilation duration and improves discharge outcomes.
-
Population-Based Models Increase Lung Cancer Screening Coverage
A scoping review of 56 programs finds population-based strategies reach up to 40% of at-risk adults, exceeding referral-based models.
-
Bedside AI Analyzes EEG to Predict Cardiac Arrest Outcomes
A deep learning tool integrated into ICU monitors provides continuous prognostic trajectories for comatose patients within 36 hours.
-
Pediatric HIV Linked to Reduced Auditory Cortex Activation Despite Normal Hearing
Functional MRI reveals central auditory processing deficits in children with HIV that may bypass standard clinical audiometry.
-
Maternal Third-Trimester Vaccination Lowers Infant COVID-19 Hospitalization Risk
Prepregnancy vaccination fails to protect infants, while third-trimester mRNA doses reduce hospitalization risk by over 60 percent.
-
Fontan Registry Reveals High Comorbidity and Anxiety Rates in Adults
A multi-institutional study of 1,121 patients shows that nearly half of adults with Fontan circulation require treatment for anxiety.
-
Liver Resection and Chemotherapy Extend Survival in Incidental Gallbladder Cancer
A UK multicenter study shows radical resection and adjuvant therapy significantly improve outcomes for cancer found after cholecystectomy.
-
Baseline Connectivity Predicts Anxiety Improvement in Prefrontal TMS Trial
Pre-treatment neural architecture, rather than post-stimulation connectivity changes, correlates with clinical recovery in patients.
-
Acute Neurological Symptoms Predict Mortality in Heat-Related Illness
A Japanese study of 2,961 patients finds that impaired consciousness and seizures increase the risk of in-hospital death sevenfold.
-
Seven-Day Low-Plastic Intervention Lowers Urinary Phthalates and Bisphenol A
A randomized trial shows that minimizing plastic contact in food and personal care reduces endocrine disruptors linked to metabolic risk.