The Briefing
Continuous newsroom coverage of clinically relevant evidence — newest first.
Earlier
24 stories-
Donor-Derived Anti-CD33 CAR T-Cells Show Safety in Relapsed AML Post-Transplant
A phase 1/2 trial of VCAR33 demonstrates manageable toxicity and preliminary activity in patients with relapsed or MRD-positive disease.
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Preoperative Antifibrinolytics Reduce Transfusions After Vascular Surgery
A multi-hospital study finds early administration of tranexamic acid or epsilon-aminocaproic acid lowers transfusion needs by 43 percent.
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Creative Adolescents Show Higher Neural Synchrony During Complex Film Viewing
Functional MRI data reveal that highly creative youth exhibit unique attentional alignment when processing non-linear cinematic montage.
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Training-Free AI Framework Automates Radiographic Morphometry Across Multiple Joints
A generalist landmark matching model achieves measurement accuracy comparable to radiologists without requiring anatomy-specific datasets.
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Early Thrombectomy Reduces Intubation in Intermediate-Risk Pulmonary Embolism
Intervention within 12 hours improves hemodynamic recovery and lowers ventilation risk despite similar mortality to delayed procedures.
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ME/CFS Linked to Reduced Bioactive Cortisol and Heightened Feedback Sensitivity
A meta-analysis of 46 studies confirms a neuroendocrine signature of low cortisol and HPA-axis hyporeactivity in chronic fatigue patients.
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DSDO Lenses Reduce Axial Elongation More Than DIMS in Myopic Children
A multicenter study of 1,541 participants shows DSDO lenses also suppress physiological eye growth in non-myopic children over 12 months.
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Liver Stiffness Better Reflects Cumulative Hepatic Injury Than Iron Concentration in Thalassemia
Elastography identifies advanced fibrosis in transfusion-dependent patients even when iron levels are well-controlled by chelation therapy.
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Low-Burden COPD Exacerbations Predict Future Respiratory Events
Even home-managed symptoms or a single moderate event correlate with structural lung damage and increased risk of future crises.
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Neural Responses to Reward Uncertainty Linked to Adolescent Anxiety and Anhedonia
Striatal and default network activity during uncertain reward tasks correlates with symptom severity in medication-free adolescents.
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Baricitinib Noninferior to Etanercept for Reducing Ultrasound-Assessed Synovitis
A phase IV trial shows baricitinib, with or without methotrexate, matches etanercept in objective measures of joint inflammation.
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Quantiferon-CMV Guided Prophylaxis Fails to Lower Infection in Seropositive Kidney Recipients
Early post-transplant immune monitoring did not reduce infection rates compared to standard preemptive therapy in low-risk patients.
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Kratom Leaf Extract Alleviates Stress-Induced Bladder Dysfunction in Male Mice
Oral mitragynine reduces bladder pain, mast cell infiltration, and muscarinic hyperreactivity in a murine model of chronic stress.
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Oral Dysbiosis Linked to Systemic Inflammation and Autism Symptoms
Review identifies enrichment of Porphyromonas and Tannerella as potential drivers of neurodevelopmental patterns via the oral-brain axis.
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Guillain-Barré Syndrome Incidence Declined 9% in Japan During the Pandemic
A nationwide survey reveals a shift toward demyelinating subtypes and older patients as conventional infectious triggers decreased.
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Telehealth and In-Person Lung Cancer Screening Consultations Show Equivalent Quality
A study of Veterans Affairs patients found no significant difference in shared decision-making quality or scan adherence between modalities.
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![[89Zr]girentuximab PET Identifies Any Renal Malignancy with 98% Positive Predictive Value](/images/thumb/384/89zrgirentuximab-pet-identifies-any-renal-malignan-April-01-2026.jpg)
[89Zr]girentuximab PET Identifies Any Renal Malignancy with 98% Positive Predictive Value
A secondary analysis of the ZIRCON trial indicates the CAIX-targeted tracer detects non-clear cell subtypes with high clinical accuracy.
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Remote Ischaemic Preconditioning Fails to Prevent Postoperative Myocardial Injury
A randomized trial of two-session preconditioning in abdominal surgery shows no reduction in injury and a paradoxical troponin increase.
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Oncology Providers Prioritize Social Support and Symptom Control at End-of-Life
A qualitative study of 49 clinicians reveals how personal values differ by career stage and may influence patient-centered care.
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One in Three ICH Patients on Antithrombotics Lack Clinical Indication
A retrospective study finds 30.4% of patients with intracranial hemorrhage were taking unindicated anticoagulants or antiplatelets.
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African Populations Underrepresented in High-Impact Clinical Trials
A systematic review of 2,472 trials shows that only 0.6% of cardiovascular studies were conducted exclusively in Africa.
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Metacognitive Beliefs Condition the Link Between Somatic Symptoms and Health Anxiety
A survey of 564 adults shows anxiety sensitivity only amplifies health anxiety when patients hold high beliefs about their biased thinking.
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Emotional Trauma Drives Adolescent Alexithymia Through Gender-Specific Pathways
Network analysis of 2,447 adolescents identifies emotional abuse and neglect as primary drivers of specific emotional processing deficits.
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Injectable Antipsychotics Reduce Hospitalization and Relapse in Bipolar Disorder
A mirror-image study shows paliperidone and aripiprazole long-acting formulations significantly lower psychiatric service use and relapse.