The Briefing
Continuous newsroom coverage of clinically relevant evidence — newest first.
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CT Vascular Pruning Markers Identify Chronic Vasculopathy in Sickle Cell Disease
Automated quantification of small pulmonary vessels correlates with impaired gas exchange and history of pulmonary hypertension.
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Wind Instruments Trigger Intraocular Pressure Spikes During High-Pitch Play
A cross-sectional study of 63 musicians finds transient ocular hypertension in wind players independent of the Valsalva maneuver.
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Blood MicroRNA Signatures Correlate With Hippocampal Volume and Atrophy Rates
Specific microRNA expression patterns in whole blood may serve as early markers for structural brain changes and neurodegenerative risk.
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Physical Therapy Improves Function More Than CBT in Chronic Low Back Pain
A sequential randomized trial finds physical therapy superior for initial functional gains, though secondary strategies show no difference.
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Occult Hypertension Linked to Coronary Plaque in Male Masters Athletes
Hidden hypertension and exercise-induced blood pressure spikes correlate with high-risk coronary atherosclerosis in asymptomatic athletes.
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Counterconditioning Stabilizes Neural Safety Signals in PTSD
Functional MRI shows pairing threat stimuli with positive outcomes reinforces safety patterns in the ventromedial prefrontal cortex.
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Deep Learning Synthesizes Contrast-Enhanced CT and MRI Scans
A scoping review of 56 studies shows high image fidelity but limited evidence for diagnostic interchangeability in clinical practice.
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Early Palliative Referral Improves End-of-Life Care Regardless of Visit Frequency
Timing of referral for metastatic solid tumors significantly impacts hospice enrollment and ICU use more than the total number of visits.
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Peritruncal Blood Volume Predicts Shunt Dependency and Functional Recovery in aSAH
Infratentorial hematoma volume shows stronger associations with long-term outcomes than traditional Fisher scales in subarachnoid hemorrhage.
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Subjective Cognitive Deficits Predict Poor Antidepressant Response in MDD
Smartphone-based monitoring of patient-reported cognitive dysfunction identifies outpatients at risk for suboptimal treatment outcomes.
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Social Media Addiction Linked to Hopelessness and Anhedonia in Youth
Network analysis identifies mood modification and conflict as key bridge symptoms connecting digital addiction to clinical distress.
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Exercise Linked to Greater Mortality Reduction in Depressed Older Adults
A cohort study of 5323 seniors shows that physical activity provides a 32% mortality risk reduction for those with depressive symptoms.
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Hypochondriasis Risk Increases with Genetic Relatedness in Large Cohort
A Swedish study of 5.8 million people finds full siblings of patients have a ninefold higher risk of health anxiety.
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Polymer Sac Embolization Increases Aneurysm Regression After EVAR
A multicenter analysis shows shape memory polymer plugs improve one-year sac regression rates to 79% compared with 51% for standard repair.
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Palliative Telecare Fails to Improve Goal Concordance in Cardiopulmonary Disease
A randomized trial of nurse and social worker-led phone interventions found no change in treatment alignment or patient uncertainty.
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Low-Value Evaluation Increases Decision Thresholds and Neural Conflict in Choice Tasks
Shifting focus toward negative attributes slows evidence accumulation and increases attentional demand without altering final outcomes.
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Specific RehaCom Modules Predict Processing Speed Gains in Progressive Multiple Sclerosis
Progression in attention-based modules and baseline characteristics like IQ and age determine cognitive outcomes in progressive MS.
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NIRS-Guided Resuscitation Improves Early Motor Scores in Preterm Infants
A COSGOD III sub-study shows that monitoring cerebral oxygenation in the first 15 minutes of life correlates with better motor repertoire.
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Targeted Agents Fail to Extend Survival in Pediatric Brainstem Glioma
The BIOMEDE trial finds no survival benefit for erlotinib, dasatinib, or everolimus, but identifies TP53 as a key prognostic marker.
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Shared Mitochondrial Pathways Identified Across 23 Neurodevelopmental Risk Genes
Researchers used CRISPR to map how diverse genetic mutations converge on common molecular targets, allowing for drug testing in animal models.
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Donor Factors and Platelet Degranulation Drive Whole Blood Antifibrinolytic Variability
A study of 28 whole blood units identifies distinct high and low PAI-1 activity cohorts linked to endothelial markers and storage lesions.
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Balanced Fluids and Saline Show Similar Outcomes in Pediatric Septic Shock
A large trial of over 8,000 children found no difference in kidney events or mortality between balanced crystalloids and 0.9% saline.
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Neonatal Meconium Aspiration Increases Preschool Asthma Risk by 64 Percent
A retrospective cohort study of 326,940 children links neonatal lung injury from meconium aspiration to long-term respiratory morbidity.
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Virtual Neurology Visits Show Similar 90-Day Acute Care Utilization Rates
A multicenter cohort study finds no significant difference in emergency department visits or hospitalizations after virtual consultations.