Polygenic Risk Scores Identify High Susceptibility for Eight Cardiovascular Traits

Cardiovascular disease remains the leading cause of morbidity globally, yet traditional risk assessment tools often fail to capture the full spectrum of inherited susceptibility [1]. While clinical guidelines emphasize managing modifiable factors like lipids and blood pressure, the underlying genetic architecture of these conditions points to a need for more individualized diagnostic tools [2, 3]. Polygenic risk scores, which aggregate the effects of thousands of genetic variants to quantify inherited disease risk, have emerged as a potential method to refine risk stratification beyond conventional models [4]. However, the transition from research biobanks to actionable clinical reports has been hindered by a lack of standardized implementation frameworks and real-world validation [5, 6]. To bridge this gap, researchers have developed and validated an integrated reporting system that evaluates genetic susceptibility across eight distinct cardiovascular pathologies.