Trial Watch · Psychiatry & Cognitive Neurology
Clinical trials in Psychiatry & Cognitive Neurology, ranked by methodological rigor and ordered by most recent.
Multimodal AI System Matches Clinicians in Simulated Telehealth Diagnostics
A new AI system, multimodal AMIE, integrates diverse data types to achieve high diagnostic accuracy and conversational quality in simulated telehealth
Randomized Controlled Trial
Tea Polyphenols Mitigate Brain Changes, Anxiety in Aged Diabetic Rats
A preclinical study in aged T2DM rats suggests tea polyphenol intervention may improve hippocampal structure, function, and behavior.
Non-Randomized Controlled Trial
Sternal Vibration Plus Mindfulness Improves Body Awareness, White Matter in Trauma
A study in trauma-exposed adults found sternal vibration combined with mindfulness meditation enhanced interoceptive awareness and increased neurite.
Randomized Controlled Trial
CTBS to Right DLPFC Reduces Heavy Drinking Relapse Risk in AUD Over 12 Months
Continuous theta-burst stimulation to the right DLPFC lowered heavy-drinking relapse risk in AUD over 12 months in a randomized trial.
Non-Randomized Controlled Trial
ED Nudge Strategy Increases Naltrexone Prescribing for Alcohol Misuse
A multicomponent emergency department protocol significantly raised naltrexone initiation for patients with alcohol-related diagnoses.
Randomized Controlled Trial
Intracranial Stimulation Prevents Attentional Lapses in Children
A new study identifies a real-time neural signature for attentional control, enabling targeted intervention to improve attention shifts.
Randomized Controlled Trial
Accelerated Deep TMS Protocols Show High Remission Rates in Depression
A randomized trial finds that 10-day accelerated deep TMS protocols achieve 42% to 50% remission rates, exceeding pharmacotherapy alone.
Randomized Controlled Trial
Testosterone Therapy Improves Sexual Function After Radical Prostatectomy
A phase 2 trial shows 12 weeks of testosterone cypionate enhances libido and body composition without triggering biochemical recurrence.
Randomized Controlled Trial
Magnetic Seizure Therapy Limits Memory Loss in Bipolar Depression Trial
A randomized pilot study shows magnetic seizure therapy matches the efficacy of ultrabrief ECT while reducing cognitive adverse effects.
Randomized Controlled Trial
Digital Therapeutic App Reduces Chronic Tinnitus Distress in Randomized Trial
A mobile application delivering cognitive behavioral therapy significantly improved Tinnitus Handicap Inventory scores over 24 weeks.
Non-Randomized Controlled Trial
Autologous Mesenchymal Cells Reduce Neuroinflammation in Chronic Brain Injury
A Phase 1/2a trial shows intravenous stromal cells improve white matter integrity and reduce immune cell density in the chronic TBI brain.
Randomized Controlled Trial
Mindfulness Adjunct Lowers Anxiety Scores in Medicated Adults With GAD
An 8-week mindfulness program added to pharmacotherapy improved clinician-rated anxiety, sleep quality, and psychosocial functioning.
Randomized Controlled Trial
Prefrontal Stimulation Amplifies Placebo Mood Response in Depression
Intermittent theta burst stimulation of the dorsomedial prefrontal cortex modulates the default mode network to enhance expectancy effects.
Randomized Controlled Trial
Psychotherapy Shows Large, Durable Effects in Treatment-Resistant Depression
A reanalysis of trial data suggests clinical gains stem from simultaneous psychological shifts rather than sequential changes in defense.
Randomized Controlled Trial
Telehealth Hypnotic Cognitive Therapy Reduces Chronic Pain After Spinal Cord Injury
A randomized trial demonstrates that remote delivery of hypnotic cognitive therapy significantly lowers pain intensity and depression.
Randomized Controlled Trial
Group CBT Reduces Hostile Attribution Bias in Young Adults With ASD Traits
A pilot study finds that targeting social cognitive distortions improves communication and quality of life through distinct pathways.
Randomized Controlled Trial
Digital Exercise and Interoceptive Training Lower Acute Depression Scores in Young Adults
A randomized trial found significant short-term symptom reduction, though benefits did not persist at one- or three-month follow-up.
Randomized Controlled Trial
Group Cognitive Therapy Reduces Negative Symptoms in Early Psychosis
A pilot trial shows rumination-focused therapy added to standard care significantly improves negative symptoms and repetitive thinking.
Randomized Controlled Trial
Intranasal Ketamine Reduces Existential Distress in Advanced Cancer Patients
Secondary analysis shows three doses of intranasal ketamine improve death-related anxiety and existential well-being in palliative care.
Randomized Controlled Trial
Behavioral Activation Reduces Pain During Smoking Cessation in Depressed Adults
A secondary analysis finds that behavioral activation therapy significantly lowers bodily pain scores compared to standard cessation care.
Randomized Controlled Trial
Digital and Primary Care Intervention Reduces Adolescent Depressive Symptoms in Slums
A randomized trial in India shows a multimedia campaign and digital tools improve mental health literacy and lower PHQ-9 scores.
Randomized Controlled Trial
2C-B Shows Empathogenic and Psychedelic Effects with Low Cardiovascular Strain
A crossover trial compares 30 mg of 2C-B to MDMA and psilocybin, finding similar emotional empathy and a shorter five-hour duration.
Randomized Controlled Trial
Interdisciplinary Whole Health Teams Improve Chronic Pain Function Over Standard Care
A randomized trial of 764 veterans shows that value-aligned team care reduces pain interference more than group therapy or usual care.
Randomized Controlled Trial
Semaglutide Improves Reward-Based Motivation in Patients With Major Depressive Disorder
A randomized trial shows oral semaglutide reduces the perceived cost of physical effort in patients with depression and elevated BMI.
Randomized Controlled Trial
Online Therapist-Assisted Program Reduces Posttraumatic Stress in Injured Children
A randomized trial shows a digital cognitive behavioral intervention lowers symptom scores for six months following pediatric hospitalization.
Randomized Controlled Trial
Symptom-Based Dosing Reduces Discharge Time in Neonatal Opioid Withdrawal
A cluster randomized trial shows symptom-based dosing shortens medical readiness for discharge when paired with the Eat, Sleep, Console model.
Randomized Controlled Trial
Luvadaxistat Fails to Improve Schizophrenia Cognition in Phase 2 Trial
The ERUDITE study found no significant cognitive benefit from adding the D-amino acid oxidase inhibitor to stable antipsychotic therapy.
Randomized Controlled Trial
Physical Therapy Improves Function More Than CBT in Chronic Low Back Pain
A sequential randomized trial finds physical therapy superior for initial functional gains, though secondary strategies show no difference.
Randomized Controlled Trial
Counterconditioning Stabilizes Neural Safety Signals in PTSD
Functional MRI shows pairing threat stimuli with positive outcomes reinforces safety patterns in the ventromedial prefrontal cortex.
Non-Randomized Controlled Trial
Pitch Gestures Increase Prefrontal Activation During Mandarin Tone Sandhi Perception
Training with physical gestures strengthens functional connectivity in the left dorsolateral prefrontal cortex to improve auditory discrimination.