Trial Watch · Psychiatry & Cognitive Neurology
Clinical trials in Psychiatry & Cognitive Neurology, ranked by methodological rigor and ordered by most recent.
Multimodal AI System Matches Clinicians in Simulated Telehealth Diagnostics
A new AI system, multimodal AMIE, integrates diverse data types to achieve high diagnostic accuracy and conversational quality in simulated telehealth
Randomized Controlled Trial
LB-102 Reduces Acute Schizophrenia Symptoms in Phase 2 Trial
A randomized trial of the benzamide derivative LB-102 demonstrated significant PANSS score improvements across three daily dose levels.
Non-Randomized Controlled Trial
Telepractice PTR-F Improves Parent Fidelity in Chinese American Families
A culturally adapted behavioral intervention delivered remotely increased parent adherence and reduced challenging behaviors in autistic children.
Randomized Controlled Trial
Dialectical Behavior Therapy and Schema Therapy Show Similar Efficacy for BPD
A 3-year randomized trial found no significant difference in symptom reduction or dropout between these two intensive psychotherapies.
Randomized Controlled Trial
Behavioral Nursing Model Improves Glycemic Control and Cognition in Older Diabetes Patients
A three-month Information-Motivation-Behavioral Skills intervention reduced HbA1c and psychological distress while improving cognitive scores.
Randomized Controlled Trial
Baseline Connectivity Predicts Anxiety Improvement in Prefrontal TMS Trial
Pre-treatment neural architecture, rather than post-stimulation connectivity changes, correlates with clinical recovery in patients.
Randomized Controlled Trial
Coping and Self-Efficacy Mediate Mood Improvements in Brain Tumor Caregivers
A secondary analysis of a randomized trial shows that a telehealth intervention reduces anxiety and depression by targeting specific psychological mec
Randomized Controlled Trial
Chronotherapeutic Protocol Advances Circadian Timing and Extends Adolescent Sleep
A two-week intervention using light-modulating glasses and scheduling increased weeknight sleep by 47 minutes in high school students.
Randomized Controlled Trial
High-Intensity tACS Improves Chronic Insomnia by Modulating Brain Networks
A randomized trial shows 15 mA stimulation reduces sleep index scores and reorganizes functional connectivity in hyperarousal circuits.
Randomized Controlled Trial
Apps for Alcohol Use Do Not Improve Mood Beyond Standard Care
In a randomized trial, digital tools added to standard care did not further reduce depression or anxiety in adults with alcohol dependence.
Non-Randomized Controlled Trial
Structured Exercise Improves Sleep and Executive Function in Preteens With Autism
A 10-to-12-week physical activity program objectively reduced sleep fragmentation and improved problem-solving in children with autism.
Randomized Controlled Trial
Web-Based School Program Reduces New-Onset Mental Health Problems
An eight-session internet intervention focused on stress management lowered the one-year incidence of mental health issues from 28% to 21%.
Randomized Controlled Trial
Decision Tool Reduces Antidepressant Discontinuation in Depression
A web-based system personalizing antidepressant selection kept more patients on therapy at 8 weeks and improved symptoms at 24 weeks.
Non-Randomized Controlled Trial
Social Skills Training Modulates Local Connectivity in the Autistic Social Brain
A 14-week intervention reduces regional homogeneity in the medial frontal gyrus, correlating with improved social responsiveness scores.
Randomized Controlled Trial
Hybrid Dialectical Behavior Therapy Reduces Suicidal Ideation in Adolescents
A year-long trial shows combining online and offline DBT improves emotional regulation and depressive symptoms in self-injuring youth.
Randomized Controlled Trial
Clozapine Increases Response After One Failed Antipsychotic in Early Psychosis
A sequential trial reveals that switching to clozapine after a single failed antipsychotic yields a 62.5% response rate in early psychosis.