The Briefing · Psychiatry & Cognitive Neurology
Continuous newsroom coverage of evidence in Psychiatry & Cognitive Neurology — newest first.
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Schizophrenia Patients Lack Neural Mismatch Response to Unmasked Faces
Patients with schizophrenia fail to generate a normal brain response when internal predictions of a face conflict with new visual input.
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Plasma p-Tau217 Matches PET for Modeling Alzheimer's Timelines
Plasma p-tau217 accurately estimates the onset of amyloid and tau pathology, offering an accessible alternative to expensive PET scans.
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Altered Cortical Myelination in OCD Links to Specific Symptoms
A multisite MRI analysis reveals that adults with obsessive-compulsive disorder show altered intracortical myelination in frontal regions.
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Web-Based School Program Reduces New-Onset Mental Health Problems
An eight-session internet intervention focused on stress management lowered the one-year incidence of mental health issues from 28% to 21%.
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Paid Social Media Boosts Community Outreach in Prehospital Trials
A retrospective review of a 20-site pediatric trial shows paid Facebook ads reach significantly more people than free institutional posts.
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NMDA Receptor Ablation in Adolescent Mice Triggers Synaptic Rebound
Removing NMDA receptors in the adolescent mouse prefrontal cortex causes an initial spine loss followed by a compensatory synaptic rebound.
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Plasma GFAP and NfL Predict Long-Term Mortality in Older Adults
Elevated baseline levels of GFAP and NfL strongly correlate with future risk of all-cause, dementia, and cardiovascular death.
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Algorithm Predicts Parkinsonism Pathology From Clinical Symptoms
A machine learning tool trained on brain bank data uses 23 clinical parameters to accurately predict post-mortem pathology in parkinsonism.
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Brain Imaging Maps How Deep Brain Stimulation Alters Parkinson's Circuits
Extensive functional MRI data from 14 patients reveals that cortical connectivity patterns can predict clinical outcomes of stimulation.
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Social Isolation Linked to Mood Episodes in Youth Bipolar Disorder
A scoping review of 522 patients identifies loneliness as a marker of poor psychosocial function and altered neural social processing.
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Decision Tool Reduces Antidepressant Discontinuation in Depression
A web-based system personalizing antidepressant selection kept more patients on therapy at 8 weeks and improved symptoms at 24 weeks.
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Glutamate Levels Link to EEG Hyperexcitability in Borderline Personality Disorder
Metabolic imaging reveals that glutamate ratios in the nucleus accumbens and cingulate cortex correlate with neural instability markers.
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Seven Hours of Sleep Maximizes Depression Risk Reduction in Older Adults
A national cross-sectional study reveals a non-linear relationship where the mental health benefits of sleep attenuate after seven hours.
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ADHD Linked to Attenuated Rightward Structural Asymmetry in Children
MRI data reveal that reduced right-hemisphere dominance in frontal and striatal regions correlates with impaired attention and timing.
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LGBTQ+ EMS Clinicians Balance Professional Identity and Disclosure
A qualitative analysis reveals how LGBTQ+ prehospital clinicians navigate workplace disclosure while prioritizing their clinical skills.
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Sleep Under 6.7 Hours Linked to Depression in Opioid Users
A U-shaped dose-response curve reveals that insufficient sleep increases depression risk by 60% among adults taking prescription opioids.
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Digital Dyadic Interventions Improve Cognition and Reduce Caregiver Burden
A review of 38 studies finds digital tools like mobile apps and remote platforms enhance patient cognition and ease caregiver burden.
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Real-World CBT Improves Distress but Not Pain in Functional Neurological Disorder
Routine clinical data from 234 adults shows cognitive behavioral therapy significantly reduces psychological distress but not physical pain.
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Social Skills Training Modulates Local Connectivity in the Autistic Social Brain
A 14-week intervention reduces regional homogeneity in the medial frontal gyrus, correlating with improved social responsiveness scores.
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Paranoia and Distress Aversion Predict Faster Borderline Personality Disorder Response
Female patients with borderline personality disorder exhibiting higher baseline paranoia show faster symptom decline during residential care.
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Conscientiousness and Resilience Link to Special Forces Selection Success
A study of German Special Forces candidates links cognitive performance, conscientiousness, and resilience to objective selection success.
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Impulsivity Traits Mediate Childhood Trauma and Subjective Health Burdens
Nearly one-third of adults with childhood trauma report subjective health impacts without a formal psychiatric diagnosis.
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Executive Function Drivers of Autism Social Deficits Shift With Age
While executive function consistently impacts social skills in autism, the specific cognitive domains involved change as patients age.
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Childhood Adversity and Trafficking Severity Predict Survivor Recovery
A survey of 350 U.S. survivors shows that early trauma and exploitation intensity drive long-term economic and psychological outcomes.