The Briefing · Psychiatry & Cognitive Neurology
Continuous newsroom coverage of evidence in Psychiatry & Cognitive Neurology — newest first.
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Oral Frailty Affects 69% of Hospitalized Patients With Schizophrenia
A machine learning analysis identifies medication non-adherence and hospitalization frequency as key predictors of dental decline.
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Device Conflicts Affect 10% of Pediatric Mental Health Boarding Patients
Younger males with neurodevelopmental disorders face the highest risk of behavioral dysregulation when digital device access is restricted.
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GLP-1 Agonists Show No Increased Suicide Risk in Large Cohort
A nationwide study finds GLP-1 receptor agonists carry no higher risk of suicide attempts than other common antidiabetic medications.
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7 Tesla MRI Reveals Rapid Neural Connectivity Shifts During Cognitive Tasks
Healthy adults transition from surveillance to automated processing within minutes of mental exertion despite stable behavioral performance.
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Bitemporal ECT and rTMS Plus SSRIs Reduce Suicidal Ideation
A network meta-analysis of 58 trials finds nonconvulsive brain stimulation alone is ineffective for suicidal ideation without medication.
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Danish Registry Data Show Rising ADHD Medication Use and Sex Convergence
Prevalence tripled among girls between 2010 and 2023, though they continue to initiate treatment two years later than boys.
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Iron Deficiency Drives Dopaminergic Hypersensitivity in Rodent Restless Legs Model
A study in mice links brain iron deficiency to increased GABA release in the striatal-entopeduncular pathway, mimicking opioid withdrawal.
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Routine ICU Delirium Screening Misses 72% of Cases in Spanish Speakers
Caregiver-administered assessments can recover nearly half of missed delirium diagnoses when patient-provider language barriers exist.
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Coping and Self-Efficacy Mediate Mood Improvements in Brain Tumor Caregivers
A secondary analysis of a randomized trial shows that a telehealth intervention reduces anxiety and depression by targeting specific psychological mec
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MTOR Hyperactivation Suppresses Autophagy and Drives Neuroinflammation in Schizophrenia
Restoring cellular waste clearance via mTOR inhibition reduces pro-inflammatory cytokines and glial activation in schizophrenia models.
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Chronotherapeutic Protocol Advances Circadian Timing and Extends Adolescent Sleep
A two-week intervention using light-modulating glasses and scheduling increased weeknight sleep by 47 minutes in high school students.
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Cajanine Reduces Anxiety and Fear Extinction Deficits in Female Mice
The compound modulates the ERβ/NF-κB pathway to alleviate neuroinflammation and behavioral symptoms in a sex-specific manner.
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Elobixibat Improves Chronic Constipation in Patients With Schizophrenia or Depression
Postmarketing surveillance shows increased defecation frequency and improved stool consistency with no serious adverse drug reactions.
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Neural Rhythms in Language and Default-Mode Networks Predict Reading Recall
Combined EEG and MRI data reveal that specific frequency patterns in brain networks correlate with a patient's ability to remember text.
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High-Intensity tACS Improves Chronic Insomnia by Modulating Brain Networks
A randomized trial shows 15 mA stimulation reduces sleep index scores and reorganizes functional connectivity in hyperarousal circuits.
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Childhood Maltreatment Mediates Neural Influence on Depressive Temperament
Hippocampal and insular activity correlate with depressive traits through the subjective appraisal of early life trauma.
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Autism Shares Genetic Risk Loci With Diabetes and Heart Disease
Large-scale genomic analysis identifies 100 shared loci linking autism spectrum disorder to metabolic and cardiovascular phenotypes.
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Infrequent Healthcare Contact and Previous Attempts Linked to Intoxication at Suicide
A Finnish registry study of 6,892 deaths identifies clinical profiles and diagnostic factors associated with acute alcohol use.
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Planetary Health Diet Linked to Lower Risk of Stroke and Depression
A UK Biobank study of 69,370 adults finds high adherence to sustainable eating reduces brain disorder risk via slower biological aging.
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Resilience Alters Symptom Networks Linking Bullying to Depression in Adolescents
Network analysis reveals that low resilience strengthens the ties between social exclusion and depressive symptoms like anhedonia.
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Rising Depressive Symptoms Precede Cardiovascular Disease by Over a Decade
A longitudinal analysis of nearly 50,000 adults identifies a sustained increase in depressive symptoms as a long-term prodromal phase of CVD.
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Early DHEA Levels Predict Depression in Adolescent Males but Not Females
A longitudinal study finds that while DHEA at age nine increases risk for males, adrenal hormones do not explain higher female prevalence.
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Home-Based Prefrontal Cortex Stimulation Reduces Subjective Stress Appraisal
A feasibility study of self-administered tDCS shows high adherence and safety, though physiological stress markers remained unchanged.
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Four Months of Fingolimod Does Not Improve Anxiety or Depression in MS
A prospective study of 61 patients with relapsing-remitting MS found no significant changes in mood scores after initiating fingolimod.