Trial Watch · Emergency & Critical Care
Clinical trials in Emergency & Critical Care, ranked by methodological rigor and ordered by most recent.
Favipiravir Safe, Well-Tolerated for Mild-to-Moderate Lassa Fever
A phase 2 trial in Nigeria provides pharmacokinetic data and supports favipiravir as an alternative to ribavirin for Lassa fever.
Non-Randomized Controlled Trial
Early EEG Findings Guide Shorter Sedation After Cardiac Arrest
Patients with favorable EEG patterns within 12 hours of arrest saw mechanical ventilation and ICU stays reduced by over 50 percent.
Randomized Controlled Trial
Low-Calorie Feeding Does Not Worsen Kidney Function in Shock
A post hoc analysis of 3,036 patients shows early restrictive diets are safe for the kidneys, even with preexisting dysfunction.
Randomized Controlled Trial
Rapid Susceptibility Testing Speeds Antibiotic Adjustments but Not Outcomes
While rapid testing accelerated antibiotic adjustments by 14 hours, it did not improve 30-day survival or reduce deleterious events.
Randomized Controlled Trial
12-Week Diet and Exercise Program Improves Post-ICU Physical Function
A 12-week regimen of exercise and protein supplementation significantly improves physical functioning in long-stay ICU survivors.
Randomized Controlled Trial
Limiting ICU Wrist Restraints Fails to Increase Delirium-Free Days
A restrictive wrist-strap protocol in mechanically ventilated adults did not improve delirium-free days or increase self-extubation risk.
Randomized Controlled Trial
High-Flow Oxygen Lowers Intubation but Does Not Improve Survival
High-flow nasal cannula therapy reduces intubation rates in acute hypoxemic respiratory failure without altering 28-day mortality.
Randomized Controlled Trial
Prehospital Whole Blood Shows No Survival Benefit Over Component Therapy
A randomized trial of 616 trauma patients found prehospital whole blood did not reduce 24-hour mortality or massive transfusion needs.
Randomized Controlled Trial
Women Face Worse Functional Recovery After Intensive Care EEG
Despite similar acute management and mortality, critically ill women are half as likely as men to achieve favorable long-term recovery.
Randomized Controlled Trial
Apixaban Reduces Bleeding Risk Versus Rivaroxaban in Venous Thromboembolism
In a randomized trial of 2,760 patients, apixaban resulted in a 3.3% bleeding rate compared to 7.1% for rivaroxaban over three months.
Randomized Controlled Trial
Trial: Higher Bupivacaine Doses Do Not Improve Nerve Block Headache Relief
A randomized trial finds that low-dose, unilateral sphenopalatine ganglion blocks are as effective as higher doses for acute headaches