The Briefing · Emergency & Critical Care
Continuous newsroom coverage of evidence in Emergency & Critical Care — newest first.
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ESC 0/1-Hour Protocol Shows Higher Sensitivity Than High-STEACS Pathway
A multicenter study of 4,663 patients found the ESC algorithm maximizes NSTEMI detection while High-STEACS increases rule-out efficacy.
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Automated Ventilation Maintains Target Minute Volume in Helicopter Rescue Simulation
A crossover study shows automated ventilators achieve target ventilation more consistently than manual bagging during short-haul transport.
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Comorbidities and Technique Drive International Differences in BPA Outcomes
A multicenter study finds that occult cardiopulmonary factors and balloon size explain higher residual pressures after pulmonary angioplasty.
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One-Liter PEG-Ascorbate Improves High-Quality Inpatient Bowel Cleansing
A randomized trial shows very low-volume preparation yields superior right-colon visualization compared to 2-liter and 4-liter regimens.
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Antivirals and Birth-Dose Vaccines Reduce Hepatitis B Transmission and Cancer Risk
Comprehensive management of hepatitis B through early vaccination and targeted antiviral therapy can lower vertical transmission to under 1%.
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Antiviral Therapy and Vaccination Strategies Reduce Hepatitis B Mortality
Comprehensive management using serologic markers and antivirals can halve the risk of hepatocellular carcinoma in chronic HBV patients.
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Low Cerebral Perfusion Pressure Increases Delirium Risk After Cardiac Surgery
A cohort study of 1,759 patients suggests that maintaining the balance between arterial and venous pressures may prevent delirium.
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Hybrid Deep Learning Model Predicts 24-Hour Sepsis Mortality Using Treatment Response
A lightweight architecture integrating vasopressor titration and urine output achieves high negative predictive value for short-term risk.
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Interleukin-4 Inhibits Platelet Glycoprotein VI to Reduce Thrombosis in Mice
The anti-inflammatory cytokine IL-4 binds directly to the GPVI receptor, suppressing collagen-induced activation and clot formation.
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Structured Communication Training Improves Oncology Clinician Self-Efficacy and Reduces Distress
A multi-center initiative involving 2,271 clinicians shows that institutional mandates and incentives drive high training completion.
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Base Editing of Gamma-Globin Promoters Increases Fetal Hemoglobin in Sickle Cell Disease
Interim phase 1-2 data show risto-cel achieves 60% fetal hemoglobin and eliminates severe vaso-occlusive crises in 31 patients.
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Black Children Show High Skin Disease Burden but Low Dermatology Use
A multicenter study of 536,776 pediatric patients reveals significant racial gaps in specialty care access for common skin conditions.
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Manual Pressure Augmentation During Defibrillation Does Not Improve Survival
A randomized trial found that while manual pressure reduces transthoracic impedance, it does not increase survival to hospital discharge.
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Next-Generation Troponin T Assay Reduces Myocardial Injury Classification
The sixth-generation assay maintains diagnostic accuracy while identifying fewer patients with elevated levels above the reference limit.
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Endovascular Popliteal Repair Increases Reinterventions Despite Similar Limb Salvage
A 16-year study finds endovascular stent grafting for popliteal aneurysms doubles the risk of major adverse limb events at one year.
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VA Risk Calculator Predicts Long-Term Loss of Independence After Surgery
A predictive model using VA data identifies patients at risk for protracted recovery six months post-operation with high sensitivity.
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Six-Item Symptom Tool and Vestibular Screen Improve Concussion Diagnosis Accuracy
A streamlined 6-item index combined with a brief vestibular-ocular screen shows higher specificity than the standard 22-item checklist.
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ECPR May Improve Survival in Pediatric Out-of-Hospital Cardiac Arrest
A multicenter registry study finds higher survival and neurologic recovery rates with extracorporeal support despite wide confidence intervals.
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Restrictive Sepsis Resuscitation Shows No Long-Term Functional Deficits
A randomized trial finds similar cognitive and physical outcomes at 12 months for restrictive versus liberal fluid strategies in sepsis.
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Water Access and Vaccination Linked to Lower Pediatric HIV Mortality
Meta-regression of 67 cohorts identifies water access, pneumococcal vaccination, and maternal education as key predictors of survival.
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ED Boarding Times for Older Adults with Dementia Surged Between 2015 and 2022
A national analysis shows mean boarding times for geriatric patients more than doubled since 2018, reaching 501 minutes for those with dementia.
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Non-Intubated ECMO Failure Linked to Seven-Fold Increase in 90-Day Mortality
An international cohort study finds that while avoiding mechanical ventilation during ECMO is feasible, failure carries high mortality risks.
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Active Support Increases Injury Prevention Program Use in Female Athletes
In-person workshops for coaches tripled the use of injury prevention protocols, though direct impact on ACL and concussion rates remains unclear.
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Multiarm Platform Evaluates Traumatic Wound Care During War in Ukraine
Researchers implement a multistage protocol to test devices and therapies for infected wounds amid rising antimicrobial resistance.