The Briefing · Emergency & Critical Care
Continuous newsroom coverage of evidence in Emergency & Critical Care — newest first.
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Low MicroRNA-362 Linked to Acute Lung Injury After Murine Brain Trauma
Downregulation of microRNA-362-3' in extracellular vesicles fails to suppress proinflammatory TIMP-1 in a mouse model of head injury.
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First-Time Seizure Linked to Increased Risk of Systemic and Neurological Cancer
A Danish cohort study finds a fivefold increase in overall cancer risk within one year of an initial seizure in adults.
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Non-Invasive Tools Estimate Intracranial Pressure When Invasive Monitoring Is Contraindicated
A review evaluates ultrasound and imaging techniques to detect intracranial hypertension in patients with coagulopathy or liver failure.
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Pulsed Field Ablation Reduces Recurrence in Persistent Atrial Fibrillation
First-line pulsed field ablation showed a 56% success rate at 12 months compared to 30% for antiarrhythmic drugs in a randomized trial.
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Targeted Hepatitis B Birth Vaccination May Increase Neonatal Infections
A simulation of 3.6 million infants suggests replacing universal birth doses with targeted strategies could add 628 neonatal infections.
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Videolaryngoscopy Increases First-Attempt Success for Double-Lumen Tube Intubation
A multicenter trial of 916 patients shows digital visualization improves glottic view and reduces esophageal intubation rates.
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Serum Neurofilament Light Chain Tracks Acute Injury in Refractory Status Epilepticus
Elevated NfL levels distinguish cryptogenic NORSE from other seizure etiologies and correlate with poor functional outcomes at discharge.
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Heterogeneous Trial Endpoints Limit Evidence in Acute Kidney Injury
A review of 251 trials reveals inconsistent outcome definitions and measurements that hinder clinical application of renal research.
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Gastric Bypass Reversal Relieves Symptoms but Carries High Morbidity Risk
A Swedish cohort study shows 86% symptom relief after reversal, though one in four patients faces early severe complications.
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Symptom-Based Dosing Reduces Discharge Time in Neonatal Opioid Withdrawal
A cluster randomized trial shows symptom-based dosing shortens medical readiness for discharge when paired with the Eat, Sleep, Console model.
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Hemothorax Volume Under 300 mL Predicts Successful Observation
A multicenter study finds that traumatic hemothorax volume over 300 mL increases the risk of observation failure sixteenfold.
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Resuscitative Thoracotomy Yields 7.4 Percent Survival in Combat Trauma
A retrospective cohort study shows survival rates comparable to civilian trauma despite high-energy blast injuries and severe hemorrhage.
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Auricular Vagus Nerve Stimulation Manages Refractory Sympathetic Hyperactivity Post-Hemorrhage
Adjunctive neuromodulation improved tachypnea and consciousness while reducing polypharmacy in a patient with intracerebral hemorrhage.
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High-Ratio Plasma Resuscitation Reduces Mortality in Moderate Traumatic Brain Injury
A large database analysis suggests plasma-heavy transfusion improves 30-day survival for patients not requiring massive transfusion.
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Donor Factors and Platelet Degranulation Drive Whole Blood Antifibrinolytic Variability
A study of 28 whole blood units identifies distinct high and low PAI-1 activity cohorts linked to endothelial markers and storage lesions.
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Balanced Fluids and Saline Show Similar Outcomes in Pediatric Septic Shock
A large trial of over 8,000 children found no difference in kidney events or mortality between balanced crystalloids and 0.9% saline.
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Rural Residence and Social Vulnerability Predict Post-Trauma Recovery Trajectories
High social vulnerability increases home discharge odds in urban areas, while rural residence doubles the risk of prolonged hospitalization.
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Triple-Pill Therapy Reduces Recurrent Stroke Risk After Intracerebral Hemorrhage
A low-dose combination of telmisartan, amlodipine, and indapamide lowered systolic blood pressure and major cardiovascular events.
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Rural Detention Centers Drive High-Acuity EMS Volume and Long-Distance Transfers
A cross-sectional analysis reveals that 43% of emergency transports from a Georgia detention facility require 40-mile tertiary transfers.
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Early Thrombectomy Reduces Intubation Risk in Pulmonary Embolism
Intervention within 12 hours of diagnosis improves hemodynamic recovery and lowers respiratory failure rates in intermediate-risk patients.
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Cardiac Arrest Increases Mortality and Coronary Complexity in STEMI Shock
A retrospective study of 345 patients shows that cardiac arrest in cardiogenic shock signals higher SYNTAX scores and 80% 1-year mortality.
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Physician-Led Program Improves Prehospital Care for Medically Complex Children
The STARS initiative uses individualized electronic care plans and targeted EMS training to reduce unnecessary hospital transports.
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Early Thrombectomy Reduces Intubation in Intermediate-Risk Pulmonary Embolism
Intervention within 12 hours improves hemodynamic recovery and lowers ventilation risk despite similar mortality to delayed procedures.
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Remote Ischaemic Preconditioning Fails to Prevent Postoperative Myocardial Injury
A randomized trial of two-session preconditioning in abdominal surgery shows no reduction in injury and a paradoxical troponin increase.