Tezepelumab Reduces Exacerbations, Improves Lung Function in Diverse Severe Asthma Cohort
A real-world phase 4 study shows tezepelumab's effectiveness and safety across various severe asthma phenotypes and underrepresented patient groups.
Pre-SRS PD-1 Inhibitor Use Linked to Increased Neurological Deficits, Mortality
A multi-institutional study suggests administering PD-1 inhibitors before stereotactic radiosurgery in glioma patients may worsen outcomes.
Younger Brain Age Buffers Cognitive Impact of Tau Pathology
Structural brain integrity, but not education level, modifies the link between p-tau217 and cognitive performance in older adults.
Abortion Bans Linked to Shifts in Spontaneous Abortion Management
A study of commercially insured individuals finds state-level abortion bans are associated with increased expectant management and misoprostol-only…
POD1 Prolactin Levels Predict Long-Term Outcomes After Prolactinoma Resection
Postoperative day 1 prolactin levels help stratify risk for hyperprolactinemia rebound and recurrence, especially with prior dopamine agonist use.
Deep Learning Model Predicts Lung Cancer Risk from Single CT Scan in Asian Cohort
Sybil, an AI model, shows robust performance in predicting future lung cancer risk, including in never-smokers, using low-dose CT.
Autonomic Burden Linked to Cognitive Fluctuations in Lewy Body Dementia
A longitudinal study finds autonomic symptom severity correlates with neuropsychiatric burden and reduced caregiver quality of life.
Amateur Soccer Heading Linked to Acute Elevations in Neural Damage Biomarkers
A prospective study found that heading in amateur soccer acutely increases blood levels of p-tau217 and S100B, with dose-response relationships.
Four Clinical Trajectories Identify Distinct Outcomes in Acute Respiratory Failure
A multi-cohort analysis reveals predictable 14-day courses for patients with persistent acute hypoxemic respiratory failure.
Cervical Spinal Cord Injury Linked to Higher Depression Risk Than Lower-Level Injuries
A nationwide cohort study reveals patients with cervical SCI face a significantly elevated risk of depression compared to those with thoracic/lumbar.
Exome Sequencing Identifies Genetic Links in Persistent Tachypnea of Infancy
Comprehensive genetic testing reveals that persistent tachypnea of infancy often associates with underlying neurodevelopmental conditions.
Real-World Data Predicts Long-Term Poor Outcomes in Clinical High-Risk Psychosis
A new model identifies individuals at clinical high risk for psychosis who face diverse long-term adverse events, including hospitalization and suicid