Maternal Third-Trimester Vaccination Lowers Infant COVID-19 Hospitalization Risk

Protecting infants from severe respiratory infections remains a critical priority, as neonates and premature infants face a significantly higher risk of severe COVID-19 outcomes compared to older children [1]. While maternal infection with SARS-CoV-2 is associated with increased risks of preterm birth and stillbirth [2], vaccination has emerged as a safe and effective strategy to mitigate these perinatal complications [3, 4]. Beyond direct maternal protection, the transfer of antibodies through the placenta and breast milk offers a potential mechanism for shielding immune-immature infants [5]. However, the durability of this passive immunity and the optimal window for maternal immunization to ensure infant protection have remained unclear. A new study now offers fresh insights into how the timing of maternal vaccination relative to conception dictates clinical outcomes for the infant.