High-Dose Calcium Chloride Reduces 24-Hour Mortality in Trauma Patients

The management of major hemorrhage in trauma patients requires a highly coordinated, multidisciplinary approach to mitigate the lethal triad of acidosis, hypothermia, and coagulopathy [1, 2]. While modern protocols emphasize the early use of blood products to restore oxygen delivery and maintain hemostasis, the metabolic consequences of massive transfusion often introduce secondary physiological insults [3, 4]. Among these, the depletion of ionized calcium through citrate binding remains a critical concern, as calcium is an essential cofactor in the coagulation cascade and vital for myocardial contractility. Current international guidelines underscore the importance of evidence-based strategies to standardize care and improve survival in these high-acuity settings [2]. However, the precise dosing of electrolytes required to counteract transfusion-induced deficiencies remains a subject of active clinical investigation. A new study now evaluates specific supplementation ratios to determine their impact on early patient survival.