Distinct Cortical Thickness Patterns Define Positive and Negative Schizotypy

Schizotypy represents a multidimensional construct of personality traits that mirrors the symptoms of schizophrenia, serving as a subclinical marker for psychosis liability within the general population [1]. While these traits are associated with various cognitive and perceptual impairments, establishing consistent neuroanatomical markers has proven difficult due to significant methodological heterogeneity across smaller studies [1, 2]. Current clinical frameworks, such as the Hierarchical Taxonomy of Psychopathology, increasingly emphasize a dimensional approach to mental illness, suggesting that these subclinical features may share genetic and structural substrates with overt psychiatric disorders [3, 4]. Previous research has identified potential overlaps in cortical thickness between high-schizotypy individuals and those with established schizophrenia, hinting at a neurobiological continuity [5]. A new large-scale study now provides a detailed characterization of how specific schizotypy dimensions integrate into the broader architecture of the human brain.