Cesium-131 Collagen Tiles Improve Local Control in Recurrent Meningioma

Meningiomas represent the most frequent primary intracranial tumor, yet the management of aggressive subtypes remains a significant clinical hurdle for neurosurgeons and oncologists [1, 2]. While maximal surgical resection is the established first-line intervention, World Health Organization Grade 2 and 3 lesions frequently recur, often after patients have already reached the limits of external beam radiation therapy [3, 4]. For these refractory cases, systemic options such as chemotherapy or targeted molecular agents have historically yielded only marginal success, leaving a critical void in effective salvage protocols [5]. Brachytherapy, a technique involving the internal placement of radioactive sources, offers a theoretical advantage by delivering high-dose radiation directly to the resection cavity while minimizing exposure to previously irradiated healthy brain tissue [6, 7]. A recent prospective trial now provides long-term evidence on the efficacy and safety of this targeted strategy in patients with recurrent disease, offering clinicians a potential new tool for managing treatment-resistant tumors.