Most Validated Radiomics Models Lack Sufficient Training Data
A systematic review of high-impact journals finds 90% of machine learning models are undertrained, risking unreliable clinical predictions.
Inconsistent ALS Trial Analytics Increase False Positive Risk
A review of 45 trials shows that statistical method choice can swing treatment effect estimates and risk advancing ineffective therapies.
Targeted Therapies and Prognostic Scoring Improve Acute Liver Failure Outcomes
Early etiology-specific intervention and validated scoring systems are essential to optimize survival before advanced encephalopathy occurs.
Inconsistent ALS Trial Analysis Increases Risk of False Positive Results
A review of 45 clinical trials shows that statistical method choice can swing treatment effect estimates by over three standard deviations.
Biceps Tenotomy and Tenodesis Show Moderately Robust Clinical Equivalence
A meta-analysis using the reverse continuous fragility index suggests current evidence for similar outcomes is statistically stable.
Anesthesia Trials Lack Precise Definitions for Perioperative Disruptions
A review of 139 trials finds 60% fail to report how they handle events like surgery cancellations or treatment switching.
Population-Based Models Increase Lung Cancer Screening Coverage
A scoping review of 56 programs finds population-based strategies reach up to 40% of at-risk adults, exceeding referral-based models.
Preclinical Review Links Kratom to Epigenetic Changes and Cardiac Risks
Systematic analysis of 20 studies identifies HDAC2 and Rab35 as markers of dependence while highlighting CYP450 and ion channel interference.
Systematic Review Evaluates 70 Years of Neuroimaging in Extra-Sensory Perception
Analysis of 143 reports identifies potential electrophysiological markers despite widespread methodological limitations and small samples.
Ubiquinol Slows Motor Decline in Multiple System Atrophy Trial
A Phase 2 trial provides the first placebo-controlled evidence of disease modification by targeting mitochondrial dysfunction in MSA.
Mechanism-Based Care Relieves Peripheral Edema in Advanced Cancer
A scoping review of 2,223 patients suggests targeted interventions like stenting and fluid management improve short-term symptom burden.
Social Isolation Linked to Mood Episodes in Youth Bipolar Disorder
A scoping review of 522 patients identifies loneliness as a marker of poor psychosocial function and altered neural social processing.