Astegolimab Reduces COPD Exacerbations in Broad Patient Population
A pooled analysis of two trials shows astegolimab significantly lowers moderate/severe exacerbation rates in patients with frequent COPD…
Armchair Positioning Improves Oxygenation in Spontaneously Breathing ICU Patients
A randomized controlled trial found out-of-bed armchair positioning increased PaO2/FiO2 ratios compared to in-bed semi-recumbent positioning.
Tea Polyphenols Mitigate Brain Changes, Anxiety in Aged Diabetic Rats
A preclinical study in aged T2DM rats suggests tea polyphenol intervention may improve hippocampal structure, function, and behavior.
Digital Decision Aid Boosts STI Testing in ED for Young Adults
A randomized trial shows a smartphone-based tool significantly increases gonorrhea/chlamydia and pharyngeal STI testing rates in emergency department
Anti-C5a Antibody STSA-1002 Shows Favorable Safety, Reduced Mortality in ARDS
A phase 1b/2 trial indicates STSA-1002 is well tolerated and associated with lower 28-day mortality in viral pneumonia-induced ARDS.
CTBS to Right DLPFC Reduces Heavy Drinking Relapse Risk in AUD Over 12 Months
Continuous theta-burst stimulation to the right DLPFC lowered heavy-drinking relapse risk in AUD over 12 months in a randomized trial.
Dose-Sparing Polio Vaccine Matches Full-Dose Immunogenicity and Safety in Infants
An adjuvanted inactivated poliovirus vaccine with reduced antigen content demonstrates comparable immune response and safety to standard IPV.
Favipiravir Safe, Well-Tolerated for Mild-to-Moderate Lassa Fever
A phase 2 trial in Nigeria provides pharmacokinetic data and supports favipiravir as an alternative to ribavirin for Lassa fever.
Intravenous Magnesium Sulfate Reduces Rescue Analgesia for Acute Headache
A randomized trial finds adjunctive magnesium sulfate increases treatment success and patient satisfaction, despite pain reduction not meeting clinica
Multimodal AI System Matches Clinicians in Simulated Telehealth Diagnostics
A new AI system, multimodal AMIE, integrates diverse data types to achieve high diagnostic accuracy and conversational quality in simulated telehealth
Thrombectomy Improves Functional Independence in Medium-Vessel Occlusion Stroke
A randomized trial shows endovascular thrombectomy increases functional independence but also raises symptomatic intracranial hemorrhage risk in mediu
Abatacept Reduces Rheumatoid Arthritis Progression in Seropositive Palindromic Rheumatism
A randomized trial indicates abatacept significantly lowers the risk of developing rheumatoid arthritis compared to hydroxychloroquine over two years.