Delaying Infant Hepatitis B Vaccination Increases Infections and Costs
A Markov model of 3.6 million infants shows even a two-month delay in the birth dose raises mortality and healthcare expenditures.
Automated MRI Segmentation Establishes Brain Volume Norms for Very Preterm Infants
Sex-stratified reference ranges for 26 brain regions provide a clinical baseline to identify developmental deviations at term-equivalent age.
Targeted Hepatitis B Birth Vaccination May Increase Neonatal Infections
A simulation of 3.6 million infants suggests replacing universal birth doses with targeted strategies could add 628 neonatal infections.
Online Therapist-Assisted Program Reduces Posttraumatic Stress in Injured Children
A randomized trial shows a digital cognitive behavioral intervention lowers symptom scores for six months following pediatric hospitalization.
Symptom-Based Dosing Reduces Discharge Time in Neonatal Opioid Withdrawal
A cluster randomized trial shows symptom-based dosing shortens medical readiness for discharge when paired with the Eat, Sleep, Console model.
Machine Learning Model Predicts One-Year Rehospitalization in Preterm Infants
A retrospective study of 2,226 infants identifies clinical and socioeconomic factors linked to a 16.1% readmission rate.
Genetic Diagnosis and Multisuture Fusion Predict Chiari Risk in Lambdoid Synostosis
Longitudinal data suggest routine MRI screening is unnecessary for isolated unilambdoid synostosis but essential for multisuture cases.
NIRS-Guided Resuscitation Improves Early Motor Scores in Preterm Infants
A COSGOD III sub-study shows that monitoring cerebral oxygenation in the first 15 minutes of life correlates with better motor repertoire.
Targeted Agents Fail to Extend Survival in Pediatric Brainstem Glioma
The BIOMEDE trial finds no survival benefit for erlotinib, dasatinib, or everolimus, but identifies TP53 as a key prognostic marker.
Balanced Fluids and Saline Show Similar Outcomes in Pediatric Septic Shock
A large trial of over 8,000 children found no difference in kidney events or mortality between balanced crystalloids and 0.9% saline.
Neonatal Meconium Aspiration Increases Preschool Asthma Risk by 64 Percent
A retrospective cohort study of 326,940 children links neonatal lung injury from meconium aspiration to long-term respiratory morbidity.
Prenatal THC and Stress Synergistically Impair Maternal Care and Offspring Neurodevelopment
A mouse study finds combined prenatal exposures disrupt adolescent gene expression and behavior in a sex-specific manner.