Tezepelumab Reduces Exacerbations, Improves Lung Function in Diverse Severe Asthma Cohort
A real-world phase 4 study shows tezepelumab's effectiveness and safety across various severe asthma phenotypes and underrepresented patient groups.
DHODH Inhibition Targets Pyrimidine Synthesis in Chemo-Resistant B-ALL
A new study identifies dihydroorotate dehydrogenase (DHODH) as a metabolic vulnerability in B-ALL cells with active signaling.
4-Hydroxybenzoic Acid Restores Endogenous Coenzyme Q10 in COQ2-Deficient Patient
A first-in-human trial shows 4-HBA bypasses biosynthetic blocks to improve neurological and renal outcomes in primary CoQ10 deficiency.
POGO Score Shows Limited Diagnostic Value in Pediatric Videolaryngoscopy
A study of 904 pediatric intubations found the POGO score performed poorly in classifying difficult airways and predicting adverse events.
Platelet mTOR Pathway Drives Neuropathogenesis in Cerebral Malaria
A new study identifies the mechanistic target of rapamycin (mTOR) in platelets as a key mediator of brain injury in experimental cerebral malaria.
Exome Sequencing Identifies Genetic Links in Persistent Tachypnea of Infancy
Comprehensive genetic testing reveals that persistent tachypnea of infancy often associates with underlying neurodevelopmental conditions.
CANMAT launches 2024 guideline for Perinatal Mood, Anxiety, and Related Disorders
The new CANMAT guideline emphasizes routine, systematic screening for perinatal mood and anxiety disorders throughout pregnancy and up to one year.
Pediatric Burn Length of Stay Lower Than Traditional Benchmarks
A multi-institutional analysis of 1,543 pediatric burn patients updates expected hospital stay per TBSA, identifying key influencing factors.
Lamotrigine-Topiramate Duotherapy Increases Congenital Malformation Risk Fourfold
A large registry study identifies a significant risk increase for specific antiseizure drug combinations used during the first trimester.
Biallelic EIPR1 Variants Cause Neurodevelopmental Syndrome and Neutropenia
Defects in endosomal recycling and dense core vesicle biogenesis drive a spectrum of microcephaly, ataxia, and spasticity.
Hong Kong Genome Project Identifies Population-Specific Genetic Variants, Informs Prescriptions
A large-scale genomic initiative in the Chinese population reveals diagnostic rates for rare diseases and pharmacogenomic insights.
Digital Decision Aid Boosts STI Testing in ED for Young Adults
A randomized trial shows a smartphone-based tool significantly increases gonorrhea/chlamydia and pharyngeal STI testing rates in emergency department